Siyini Isifo sika-Addison, Kungani Kwenzeka? Izimpawu Nokwelashwa

Izindlala ze-adrenal zitholakala ngaphezu kwezinso. Lezi zindlala zikhiqiza amahomoni amaningi umzimba awadingayo ukuze enze imisebenzi evamile.

Isifo sika-AddisonKwenzeka lapho i-adrenal cortex ilimele futhi izindlala ze-adrenal zingakhiqizi ngokwanele amahomoni e-steroid i-cortisol ne-aldosterone.

i-cortisolilawula ukusabela komzimba ezimweni ezicindezelayo. I-Aldosterone isiza ukulawula i-sodium ne-potassium. I-adrenal cortex nayo ikhiqiza amahomoni ocansi (androgens).

Iyini i-Addison?

Isifo sika-AddisonKwenzeka lapho izindlala ze-adrenal zomuntu zingakhiqizi amahomoni amaningi abalulekile, okuhlanganisa i-cortisol futhi ngezinye izikhathi i-aldosterone, emazingeni aphezulu ngokwanele.ukungasebenzi kahle kwezindlala ze-adrenal” elinye igama lesimo esibizwa

Izindlala ze-adrenal zitholakala ngenhla nje kwezinso futhi zinendima ebalulekile ekukhiqizeni amahomoni afana ne-adrenaline nama-corticosteroids, anemisebenzi eminingi ngezikhathi zokucindezeleka okukhulu kanye nokuphila nje kwansuku zonke. 

Lawa ma-hormone ayadingeka ukuze kugcinwe i-homeostasis nokuthumela "iziyalezo" ezithweni nasezithweni zomzimba. Isifo sika-AddisonAmahomoni athintwa yikho ahlanganisa i-glucocorticoids (njenge-cortisol), i-mineralocorticoids (kuhlanganise ne-aldosterone), nama-androgens (amahomoni ocansi wesilisa).

Nakuba lesi simo singabeka ukuphila engozini kwezinye izimo, izimpawu ngokuvamile zingaphathwa ngokwelashwa kokubuyisela ama-hormone.

Izinkinga ze-Addison's Disease

Ukuphazamiseka kwe-adrenal gland

Ukuphazamiseka ekukhiqizeni ama-hormone ezindlala ze-adrenal Isifo sika-Addisonkuyabangela. Lokhu konakala kungase kubangelwe izinto eziningi, okuhlanganisa ukuphazamiseka kwe-autoimmune, isifo sofuba, noma ukukhubazeka kofuzo.

Kodwa-ke, cishe amaphesenti angama-80 wezifo eziningi ze-Addison abangelwa izimo ze-autoimmune.

Izindlala ze-adrenal ziyeka ukukhiqiza amahomoni e-steroid anele (i-cortisol ne-aldosterone) lapho amaphesenti angama-90 e-adrenal cortex ebhujiswa.

Lapho nje amazinga alawa ma-hormone eqala ukwehla, Izimpawu nezimpawu zesifo sika-Addison iqala ukuvela.

izimo ze-autoimmune

Amasosha omzimba ayindlela yokuzivikela yomzimba ngokumelene nezifo, ubuthi, noma izifo. Uma umuntu egula, amasosha omzimba akhe akhiqiza amasosha omzimba ahlasela noma yini ebangela ukuba agule.

Amasosha omzimba abanye abantu angase aqale ukuhlasela izicubu nezitho zomzimba ezinempilo – lokhu i-autoimmune disorder It ngokuthi.

Isifo sika-Addison Kulokhu, amasosha omzimba ahlasela amangqamuzana ezindlala ze-adrenal, kancane kancane anciphise umsebenzi wawo.

umphumela wesimo se-autoimmune Isifo sika-Addison, isifo se-autoimmune Addison Futhi ebizwa.

Izimbangela Zezakhi Zofuzo ze-Autoimmune Addison's Disease

Ucwaningo lwakamuva lubonise ukuthi abanye abantu abanezakhi zofuzo ezithile kungenzeka babe nesifo sokuzivikela komzimba.

Isifo sika-AddisonNakuba ufuzo lwalesi simo lungaqondwa ngokugcwele, izakhi zofuzo ezivame ukuhlotshaniswa nalesi simo ziyingxenye yofuzo olubizwa ngokuthi i-human leukocyte antigen (HLA) complex.

Le nkimbinkimbi isiza amasosha omzimba ukuba ahlukanise phakathi kwamaprotheni omzimba kanye nalawo enziwe amagciwane namagciwane.

Isifo sika-Autoimmune Addison iziguli eziningi nge i-hypothyroidism, uhlobo 1 sikashukela noma okungenani ube nesinye isifo esisodwa sokuzivikela komzimba, njenge-vitiligo.

Isifo sofuba

Isifo sofuba (TB) isifo esibangelwa amagciwane esihlasela amaphaphu futhi singasakazekela kwezinye izingxenye zomzimba. Uma i-TB ifinyelela ezindlala ze-adrenal, ingazilimaza kakhulu futhi ithinte ukukhiqizwa kwamahomoni.

Iziguli ezinesifo sofuba zisengozini enkulu yokulimala kwezindlala ze-adrenal, okusho ukuthi yazo Isifo sika-Addison kwandisa amathuba okuthuthuka.

Njengoba isifo sofuba singavamile manje, imbangela yalesi simo Isifo sika-Addison amacala nawo awavamile. Nokho, kunamazinga aphezulu emazweni lapho i-TB iyinkinga enkulu khona.

Ezinye izizathu

Isifo sika-Addison, kungabangelwa nezinye izici ezithinta izindlala ze-adrenal:

Isici sofuzo lapho izindlala ze-adrenal zingakhuli kahle

– ukopha

I-Adrenalectomy - ukususwa kokuhlinzwa kwezindlala ze-adrenal

- Amyloidosis

ukutheleleka okufana ne-HIV noma ukutheleleka okujwayelekile kweyeast

- Umdlavuza osungene ezindlala ze-adrenal

Ukungaphumeleli kwe-adrenal yesibili

Uma i-pituitary gland igula, izindlala ze-adrenal nazo zingathinteka kabi. Ngokuvamile, i-pituitary ikhiqiza i-adrenocorticotropic hormone (ACTH). Le hormone ivuselela izindlala ze-adrenal ukuthi zikhiqize amahomoni.

Uma i-pituitary ilimele noma inesifo, i-ACTH encane ikhiqizwa futhi, ngenxa yalokho, amahomoni amancane akhiqizwa yizindlala ze-adrenal, ngisho noma zona zingaguli. Lokhu kubizwa ngokuthi yi-secondary adrenal insufficiency.

Izidakamizwa

Abanye abantu abathatha ama-anabolic steroids, njengabakhi bomzimba, Isifo sika-Addison ingozi iphezulu. Ukukhiqizwa kwamahomoni, ikakhulukazi okubangelwa ukuphuza ama-steroids isikhathi eside, kungakhinyabeza ikhono lezindlala ze-adrenal ukukhiqiza amazinga amahomoni anempilo - lokhu kungandisa ingozi yokuba nesifo.

Ama-glucocorticoid afana ne-cortisone, i-hydrocortisone, i-prednisone, i-prednisolone, ne-dexamethasone enza njenge-cortisol. Ngamanye amazwi, umzimba ukholelwa ukuthi kukhona ukwanda kwe-cortisol futhi icindezela i-ACTH.

Njengoba kushiwo ngenhla, ukuncipha kwe-ACTH kubangela ukuba amahomoni amancane akhiqizwe yizindlala ezidlalayo.

Ayrıca, lupus Abantu abasebenzisa i-oral corticosteroids ezimweni ezifana nesifo samathumbu esivuvukalayo noma isifo samathumbu esivuvukalayo bese bewayeka ngokuzumayo bangase bahlangabezane nokuntuleka kwe-adrenal yesibili.

Yiziphi Izimpawu Zesifo sika-Addison?

Isifo sika-Addison Abantu abane-dandruff bangase babe nalezi zimpawu ezilandelayo:

- ubuthakathaka bemisipha

– Ubuthakathaka nokukhathala

– Ukuba mnyama kwebala lesikhumba

- Ukuncipha kwesisindo noma ukuncipha kwesifiso sokudla

– Ukwehla kwenhliziyo noma umfutho wegazi

– Amazinga kashukela aphansi

– Izilonda emlonyeni

– Izifiso zikasawoti

- Isicanucanu

– ukuhlanza

Isifo sika-Addison Abantu abaphila nalesi simo bangase babe nezimpawu ze-neuropsychiatric ezifana nalezi:

- Ukucasuka noma ukucindezeleka

– Amandla aphansi

- Ukuphazamiseka kokulala

Isifo sika-Addison uma ingalashwa isikhathi eside, Inkinga ye-Addisonian kungaba. Inkinga ye-AddisonianIzimpawu ezihambisana nayo yilezi:

- Ukukhathazeka nokucindezeleka

- delirium

- Ukuqagela okubonakalayo nokuzwayo

ongalashwanga Inkinga ye-Addisonian kungabangela ukushaqeka nokufa.

Ubani Osengozini Yesifo I-Addison?

Abantu abakulezi zimo ezilandelayo: Isifo sika-Addison basengozini enkulu yokuthi:

– Labo abanomdlavuza

- Izindawo ze-Anticoagulant (ezinciphisa igazi)

– Abalamikhuhlane engapheliyo efana lofuba

- Labo abahlinzwa ukukhipha noma iyiphi ingxenye ye-adrenal gland

- Labo abanesifo sokuzivikela komzimba esifana nesifo sikashukela sohlobo 1 noma isifo se-Graves

Sitholakala Kanjani Isifo sika-Addison?

Udokotela uzobuza ngomlando wezokwelapha kanye nezimpawu. Uzohlola umzimba futhi ahlele ukuhlolwa kwelebhu ukuze ahlole amazinga e-potassium nesodium.

Udokotela angase futhi a-ode ukuhlolwa kwe-imaging futhi alinganise izinga lamahomoni.

Ukwelashwa Kwesifo sika-Addison

Ukwelashwa kwalesi sifo kuzoncika ekutheni yini edala isimo. Udokotela angase anikeze izidakamizwa ezilawula izindlala ze-adrenal.

Kubaluleke kakhulu ukulandela uhlelo lokwelapha oludalwe udokotela. engelashiwe Isifo sika-Addison, Inkinga ye-Addisonianokungaholela.

Uma isimo singelashwa isikhathi eside futhi Inkinga ye-Addisonian Uma ithuthukele esimweni esisongela ukuphila esibizwa ngokuthi

Inkinga ye-Addisoniankubangela umfutho wegazi ophansi, i-potassium ephezulu kanye namazinga aphansi kashukela egazini.

Imithi

Kungase kudingeke ukuthi kusetshenziswe inhlanganisela yezidakamizwa ze-glucocorticoid (izidakamizwa ezilwa nokuvuvukala) ukwelapha lesi sifo. Le mithi izophuzwa impilo yakho yonke.

Kungase kunikezwe ukushintshwa kwama-hormone ukuze kuthathelwe indawo amahomoni angawenzi ama-adrenal gland.

Isifo sika-Addison Ukwelashwa Kwemvelo

dla usawoti owanele

Isifo sika-Addisonkungabangela amazinga aphansi e-aldosterone, okwandisa isidingo sikasawoti. Zama ukuthola izidingo zakho zikasawoti owandile ekudleni okunempilo okufana nomhluzi nosawoti wasolwandle.

Thatha i-calcium ne-vitamin D

Ukuthatha imishanguzo ye-corticosteroid kuye kwahlotshaniswa nengozi enkulu ye-osteoporosis nokulahlekelwa kwamathambo, okunganele. i-calcium futhi kusho ukuthi ukudla uvithamini D kubalulekile ekugcineni impilo yamathambo. 

Ukudla kwe-calcium kungandiswa ngokudla imikhiqizo yobisi efana nobisi olungaphekiwe, iyogathi, i-kefir noshizi ovutshiwe, imifino eluhlaza njengeklabishi ne-broccoli, nokudla okune-calcium eningi njengamasardine, ubhontshisi nama-alimondi.

Ivithamini D Indlela engcono kakhulu yokwandisa amazinga akho ngokwemvelo ukuchitha isikhathi esithile elangeni usuku ngalunye isikhumba sivele.

Thatha ukudla okulwa nokuvuvukala

Ukudla/iziphuzo ongazinciphisa noma uzigweme ukuze usekele amasosha omzimba zihlanganisa:

Utshwala obuningi noma i-caffeine, engaphazamisa umjikelezo wokulala futhi kubangele ukukhathazeka noma ukucindezeleka

Imithombo eminingi kashukela nama-sweeteners (okuhlanganisa isiraphu yommbila ephezulu ye-fructose, amaswidi apakishiwe, nezinhlamvu ezicolisisiwe)

- Gwema ukudla okupakishiwe nokugaywe ngangokunokwenzeka ngoba kuqukethe izinhlobo eziningi zezithako zokwenziwa, izivimbelakuvunda, ushukela, njll.

- Amafutha emifino afakwe i-hydrogen futhi acolisisiwe (ubhontshisi wesoya, i-canola, i-safflower, ubhekilanga kanye nommbila)

Zimiselenise ngokudla kwemvelo, okungacolisisiwe noma nini lapho kunokwenzeka. Ezinye zezinketho ezinhle kakhulu ezifakwe ekudleni okulwa nokuvuvukala zihlanganisa:

- Amafutha emvelo, anempilo (isb amafutha omnqumo)

- Imifino eningi (ikakhulukazi yonke imifino enamahlamvu nemifino e-cruciferous efana ne-cauliflower, i-broccoli, amahlumela aseBrussels)

- Izinhlanzi ezibanjwe zasendle (njenge-salmon, i-mackerel noma i-sardine, ehlinzeka ngama-omega-3 fatty acids eqeda ukuvuvukala)

– Imikhiqizo yezilwane esezingeni eliphezulu efunzwa utshani, idlelo elidliwe kanye ne-organic (isb. amaqanda, inyama yenkomo, inkukhu kanye ne-turkey)

Imifino yasolwandle efana nezimila zasolwandle (inani eliphezulu le-iodine ukusekela impilo yegilo)

- Usawoti wasolwandle i-Celtic noma i-Himalayan

- Ukudla okunefiber ephezulu okufana namastrawberry, imbewu ye-chia, imbewu yefilakisi, nemifino enesitashi

- Ukudla okune-probiotic okufana ne-kombucha, i-sauerkraut, iyogathi kanye ne-kefir

- I-ginger, i-turmeric, i-parsley, njll. amakhambi nezinongo

lawula ukucindezeleka

Thola ukulala kwekhwalithi futhi uphumule ngokwanele. Hlela amahora angu-10 kuya kwangu-XNUMX okulala ubusuku ngabunye, kuye ngezidingo zakho ezithile.

Ezinye izindlela zokusiza ukuphatha ukucindezeleka zihlanganisa:

- Ukwenza izinto zokuzilibazisa noma okuthile okujabulisayo nsuku zonke

– ukuzindla 

- Izindlela zokuphefumula eziphumuzayo

- Ukuchitha isikhathi ngaphandle, ekukhanyeni kwelanga nasemvelweni

- Ukugcina isimiso somsebenzi esingaguquki futhi esinengqondo

- Ukudla ngesimiso esijwayelekile futhi ugweme izinto eziningi ezivuselelayo njengotshwala, ushukela kanye ne-caffeine

- Funa usizo lochwepheshe lapho ludingeka ukuze ubhekane nezenzakalo ezibalulekile zempilo noma ukuhlukumezeka

Izithasiselo ezisekela impendulo yokucindezeleka

Ezinye izithasiselo zingasiza ukusekela amasosha omzimba futhi ubhekane nokucindezeleka. Izibonelo ezingase zisebenze yilezi:

- Amakhowe okwelapha afana ne-reishi ne-cordyceps

- Amakhambi e-Adaptogen afana ne-ashwagandha ne-astragalus

- i-ginseng

- Magnesium

-Omega-3 fatty acids

- Kanye nesengezo se-probiotic, ukuthatha i-multivitamin yekhwalithi ehlinzeka ngamavithamini B, uvithamini D, ne-calcium nakho kungasekela impilo yamathumbu futhi kuvikeleke ekuntulekeni kwezakhi.

Kwenzekani Uma Isifo sika-Addison Singelashwa?

I-Durum inkinga ye-adrenalUma iqhubeka futhi ingelashwa, abantu bangaba nezimpawu ezinzima futhi baze bafe ngokuzumayo, ngakho-ke lokhu kuyinto okufanele ithathwe ngokungathi sína kakhulu.

inkinga ye-adrenal ukungenelela ngokuvamile kuhlanganisa imijovo yedosi ephezulu ye-steroids, uketshezi, nama-electrolyte ukusiza ukubuyisela ukusebenza kwezindlala ze-adrenal kanye ne-pituitary.

Isifo sika-Addison Ingabe uhlala? Ungashiya amazwana.