Zizindikiro za Alzheimer's - Ndi Chiyani Chabwino Kwa Matenda a Alzheimer's?

Matenda a Alzheimer ndi mtundu wofala kwambiri wa dementia. Matendawa amachititsa kuti ubongo ukhale wovuta kukumbukira, kuganiza, ndi kuchita zinthu moyenera. Zizindikiro za Alzheimer's ndi chisokonezo, kuvutika kuchita ntchito zamba, zovuta zolankhulana, kuvutika kukhazikika.

Matendawa amayamba pakapita nthawi. Zizindikiro za Alzheimer's zimakula ndikukula ndipo pamapeto pake munthuyo sangathe kugwira ntchito yake ya tsiku ndi tsiku. Ngakhale kuti matendawa nthawi zambiri amawonekera mwa anthu opitirira zaka 65, palinso omwe amayamba matendawa ali aang'ono. Ena amakhala ndi matendawa kwa zaka 20, pomwe avereji ya moyo ndi eyiti.

Matendawa amaganiziridwa kuti ndi matenda amasiku ano ndipo akuti akhudza anthu 2050 miliyoni pofika 16.

Kodi Chimayambitsa Matenda a Alzheimer's?

Maphunziro okhudza zomwe zimayambitsa matenda a Alzheimer's, matenda osokonekera muubongo, amapitilira ndipo zinthu zatsopano zimaphunziridwa tsiku lililonse. Pakali pano, zomwe zimayambitsa kuwonongeka kwa neuronal zomwe zimadziwika ndi matendawa zimatha kudziwika. Palibe chidziwitso chokwanira cha zomwe zimayambitsa. Zomwe zimadziwika zomwe zimayambitsa matenda a Alzheimer's zitha kulembedwa motere;

• beta-amyloid plaque

Kuchuluka kwa mapuloteni a beta-amyloid kumawoneka muubongo wa odwala ambiri a Alzheimer's. Mapuloteniwa amasanduka zomangira m’njira za neuronal, kusokoneza ntchito ya ubongo.

• Zakudya zama protein 

Monga momwe mapuloteni a beta-amyloid muubongo wa odwala a Alzheimer amawunjikana kukhala zolembera, mapuloteni a tau amapanga ma neurofibrillary tangles (NFTs) omwe amakhudza kugwira ntchito kwa ubongo. Pamene tau imakula kukhala mitolo ngati tsitsi yotchedwa NFTs, imalepheretsa kayendedwe ka kayendetsedwe kake ndikulepheretsa kukula kwa maselo. Kenako zizindikiro za synaptic zimalephera. Tau protein tangles ndiye chizindikiro chachiwiri cha matenda a Alzheimer's motero ndi gawo lofunikira kwambiri kwa ofufuza omwe amaphunzira matendawa.

• Glutamate ndi acetylcholine 

Ubongo umagwiritsa ntchito mankhwala otchedwa neurotransmitters kutumiza zizindikiro pakati pa neurons. Pamene glutamate ikugwira ntchito mopitirira muyeso, imayika kupsinjika kwa ma neurons omwe amachititsa kukumbukira ndi kuzindikira. Kupsinjika kwapoizoni kumatanthauza kuti ma neuron sangathe kugwira ntchito bwino kapena kufooka. Acetylcholinendi neurotransmitter ina muubongo yomwe imathandizira kuphunzira ndi kukumbukira. Pamene ntchito ya acetylcholine zolandilira amachepetsa, neuronal tilinazo amachepetsa. Izi zikutanthauza kuti ma neuron ndi ofooka kwambiri kuti asalandire zizindikiro zomwe zikubwera.

• Kutupa

Zimapindulitsa pamene kutupa kuli mbali ya machiritso achilengedwe a thupi. Koma pamene mikhalidwe iyamba kuyambitsa kutupa kosatha, mavuto aakulu angabwere. Ubongo wathanzi umagwiritsa ntchito microglia kuteteza ku tizilombo toyambitsa matenda. Munthu akakhala ndi matenda a Alzheimer's, ubongo umawona ma tau node ndi mapuloteni a beta-amyloid ngati tizilombo toyambitsa matenda, zomwe zimayambitsa matenda a neuro-inflammatory omwe amayambitsa matenda a Alzheimer's.

• matenda aakulu

Kutupa ndizomwe zimayambitsa matenda a Alzheimer's. Matenda aliwonse omwe amayambitsa kutupa amatha kuthandizira kukula kwa dementia kapena Alzheimer's mwa okalamba. Matenda okhudzana ndi Alzheimer's akuphatikizapo herpesviruses aumunthu 1 ndi 2 (HHV-1/2), cytomegalovirus (CMV), picornavirus, Borna's disease virus, chlamydia pneumoniae, Helicobacter pylori, Borrelia spirochetes (matenda a Lyme), porphyromonas gingivalis, ndi Treponema. 

Zizindikiro za Alzheimer's

Matenda a Alzheimer ndi ofooka, kutanthauza kuti amakula kwambiri pakapita nthawi. Zimachitika pamene kugwirizana pakati pa maselo a ubongo otchedwa neurons ndi maselo ena a ubongo awonongeka. 

Zizindikiro zofala kwambiri ndi kukumbukira ndi kusokonezeka maganizo. Ngakhale pali kukumbukira pang'ono koyambirira, zizindikiro zoopsa monga kulephera kulankhula kapena kuchitapo kanthu kwa ena zimachitika m'magawo otsiriza a matendawa. Zizindikiro zina za matenda a Alzheimer ndi:

• zovuta kuyang'ana, 
• Kuvuta kugwira ntchito wamba 
• Chisokonezo
• Matenda okhumudwa kapena nkhawa kuphulika, 
• kusokonezeka maganizo 
• Osasochera mosavuta
• kusamvana bwino, 
• Mavuto ena akuthupi
• Mavuto olankhulana

Pamene matendawa akupita patsogolo, anthu amakumana ndi mavuto a luso lotha kuthetsa mavuto, kusunga ndalama, ndi kupanga zisankho zofunika. Zizindikiro zikamakula, odwala matenda a Alzheimer sangazindikire banja lawo, amavutika kumeza, amakhala okhumudwa ndipo amafunika kusamalidwa nthawi zonse.

Zowopsa za Matenda a Alzheimer's

Achipatala nthawi zambiri amakhulupirira kuti matenda a Alzheimer amayamba chifukwa cha kuphatikizika kwa majini ndi zinthu zina zoopsa osati chifukwa chimodzi. Ziwopsezo za matenda a Alzheimer's ndi awa:

• mbiri ya banja

Anthu omwe ali ndi wachibale wa digiri yoyamba ndi Alzheimer's ali ndi chiopsezo chowonjezeka cha matendawa.

• zaka

Chiwopsezo chokhala ndi Alzheimer's chimachulukira kawiri pazaka zisanu zilizonse atakwanitsa zaka 65.

• Kusuta

Kusuta kumathandizira kukula kwa dementia, kuphatikizapo Alzheimer's, chifukwa kumawonjezera kutupa komanso kumachepetsa kuthamanga kwa magazi mumtsempha.

• Matenda a mtima

mu ntchito ya ubongo, thanzi la mtima amatenga gawo lalikulu. Mkhalidwe uliwonse umene umawononga kayendedwe ka kayendedwe ka magazi umawonjezera chiopsezo cha Alzheimer's, kuphatikizapo matenda a mtima, sitiroko, kuthamanga kwa magazi, shuga wambiri, cholesterol, ndi mavuto a valve.

• kuvulala koopsa kwa ubongo

Kuwonongeka kwa ubongo chifukwa chovulala kumayambitsa kusokonezeka kwaubongo komanso kufa kwa maselo aubongo, ndipo ndi chiopsezo chachikulu cha matenda a Alzheimer's.

• Kukhala ndi moyo wopanda thanzi komanso kusadya bwino

Ofufuza amatcha matenda a Alzheimer's amakono chifukwa kufalikira kwa matendawa kwawonjezeka ndi kuchuluka kwa zakudya zopanda thanzi m'zikhalidwe zamakono.

• mavuto ogona

Anthu omwe ali ndi vuto la kugona kwa nthawi yayitali achulukitsa kuchuluka kwa zolembera za beta-amyloid muubongo wawo.

• kukana insulini

Makumi asanu ndi atatu pa zana aliwonse a odwala Alzheimer's insulin kukana kapena mtundu 2 shuga ali. Kukana insulini kwa nthawi yayitali kumatha kuyambitsa matenda a Alzheimer's.

• Kusokonezeka maganizo

Kupsinjika kwanthawi yayitali kapena kuzama ndizomwe zimayambitsa matenda a Alzheimer's. 

• zotayidwa

Aluminiyamu ndi chinthu chomwe chimakhala poizoni ku maselo amitsempha ndipo chingayambitse matenda a Alzheimer's.

• testosterone yochepa

Pamene tikukalamba, ma testosterone amachepa mwa amuna ndi akazi. Izi zimawonjezera chiopsezo cha matenda a Alzheimer's.

Chithandizo cha Matenda a Alzheimer's

• Alzheimer ndi matenda osachiritsika. Mankhwala amakono amapangidwa kuti ayang'ane zizindikiro za matendawa osati zomwe zimayambitsa.
• Chifukwa chakuti matendawa mwina alibe chifukwa chimodzi, machiritso enieni a Alzheimer's mwina sangapezeke.
• Ochita kafukufuku akupitilizabe kuyesa mankhwala a protein a beta-amyloid ndi tau monga momwe angathere pochiza matenda a Alzheimer's.
• Mankhwala a Alzheimer's adapangidwa kuti apititse patsogolo moyo wa odwala.
• Chifukwa chakuti mankhwala amakono amakono amayang'ana pa zizindikiro za matenda a Alzheimer's, odwala ambiri a Alzheimers amamwanso mankhwala kuti athetse khalidwe lawo.
• Maselo a muubongo akayamba kufooka, pangafunike mankhwala ndi mankhwala ena kuti athetse kukwiya, nkhawa, kuvutika maganizo, kugona, kuona zinthu zing’onozing’ono, ndi matenda ena a khalidwe la Alzheimer.

Kodi Ubwino wa Matenda a Alzheimer ndi Chiyani?

Pali mankhwala achilengedwe omwe amathandiza kuthetsa zizindikiro za Alzheimer's. Mankhwalawa amalimbikitsa moyo wathanzi, kuteteza matendawa kwa nthawi yayitali komanso kupewa kuyambika kwa dementia ndi zovuta zina zaubongo.

• kuchita masewera olimbitsa thupi

Kuchita masewera olimbitsa thupi kumakhudza kwambiri thanzi la ubongo. Odwala a Alzheimer's omwe amayenda pafupipafupi amachita bwino muzochita komanso kukhumudwa Kupezeka kwa zovuta zina zaubongo, monga

• zochita zamaganizo

Kuphunzitsa ubongo n'kofunika mofanana ndi kugwira ntchito kwa minofu. Zochita zamaganizo zolimbitsa thupi zimachepetsa zotsatira za matendawa mu midlife. Anthu omwe ali ndi malingaliro otanganidwa sakhala ndi matenda a Alzheimer's.

Zochita zamaganizidwe monga kusewera masewera, kuthetsa ma puzzles, ndi kuwerenga zimathandiza kuti mukhale olimba pamene mukukalamba.

• Vitamini E

Maphunziro, Vitamini EZotsatira zake zikuwonetsa kuti zimachepetsa neurodegeneration mwa odwala omwe ali ndi matenda a Alzheimer's ochepera mpaka ovuta. Alzheimer's imayambitsa kuwonongeka kwa okosijeni. Chifukwa chake, ma antioxidants monga vitamini E amatha kukhala chithandizo cha matendawa.

• Vitamini D

Vitamini DAmapangidwa pamene khungu limakhala ndi kuwala kwa dzuwa. Amagwira ntchito ndi calcium kuti apange mafupa olimba. Zimathandizira kuwongolera chitetezo chamthupi ndipo ndizofunikira pamayendedwe amoyo wa maselo amunthu monga ma cell aubongo.

Odwala ambiri omwe ali ndi matenda a Alzheimer's ndi matenda ena a dementia alibe vitamini D. Kuwonekera kwa kuwala kwachilengedwe kumalimbikitsa kugona mokwanira, makamaka kwa odwala omwe ali ndi matenda aakulu a Alzheimer's.

• Melatonin

Kuwonjezera pa kugona bwino melatoninIli ndi maubwino ambiri kwa omwe ali ndi matenda a Alzheimer's. Kafukufuku waposachedwa adawona momwe melatonin imagwirira ntchito ngati chithandizo chotsekereza nitric oxide mwa odwala a Alzheimer's. Odwala a Alzheimer's ali ndi ntchito yochepa ya melatonin receptors MT1 ndi MT2.

• manganese ndi potaziyamu

kusowa kwa manganese Ndichiwopsezo cha matenda a Alzheimer's. Zokwanira potaziyamu Popanda izo, thupi silingathe kupanga beta-amyloids moyenera ndikuwonjezera kupsinjika kwa okosijeni ndi kutupa kumawonedwa.

Kuchuluka kwa potaziyamu ndi magnesium kumapangitsa kuti chidziwitso chizigwira ntchito ndikulepheretsa kuyambika kwa matenda a Alzheimer's.

• zomera zachilengedwe

Zomera zimakhala ndi zinthu zambiri zobwezeretsa komanso zochiritsa. Pali zitsamba zina zomwe zingathandize kuti ubongo ukhale wofunikira kuti uteteze matenda a Alzheimer's.

duwa ve turmericzawonedwa kukhala zopindulitsa kwa odwala Alzheimer. Chifukwa cha anti-inflammatory and antioxidant properties, curcumin imapangitsa kuti chidziwitso chikhale bwino mwa kuchepetsa mapangidwe a beta-amyloid plaques.

• ketosis

Ketosis ndikugwiritsa ntchito mafuta osungidwa kuti apange mphamvu. Thupi likapatsidwa ma ketoni oyenerera, monga ma triglycerides apakati omwe amapezeka mu kokonati mafuta, odwala a Alzheimer amatha kusintha kukumbukira kwawo.

Kulimbikitsa ketosis, kulimbikitsa thupi kugwiritsa ntchito mafuta m'malo mwa shuga kusala kudya kwapakatikati ndi kuchepa kwa ma carbohydrate zakudya za ketogenic zoyenera. Mu ketosis, thupi limapanga kupsinjika kochepa kwa okosijeni ndipo limapereka mphamvu ya mitochondrial yogwira ntchito ku ubongo. Izi zimachepetsa milingo ya glutamate ndikulimbikitsa kugwira ntchito kwaubongo wathanzi.

• mafuta

Kugwiritsa ntchito mafuta a azitona ngati chakudya Zakudya za Mediterraneanwasonyeza zotsatira zopindulitsa kwa odwala Alzheimer. Poyesa nyama, mafuta a azitona amathandizira kukumbukira komanso kulimbikitsa kukula kwa maselo atsopano. mafutaPopeza imathandizira kuchepetsa mapangidwe a beta-amyloid plaque, imatha kuchedwa ndikuletsa kuyambika kwa matenda a Alzheimer's.

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