Izimpawu Ze-Alzheimer - Yini Elungele Isifo I-Alzheimer's?

Isifo i-Alzheimer wuhlobo oluvame kakhulu lokuwohloka komqondo. Lesi sifo sidala izinkinga ngekhono lobuchopho lokukhumbula, ukucabanga, nokwenza ngendlela efanele. Izimpawu ze-Alzheimer's zihlanganisa ukudideka, ubunzima bokwenza imisebenzi evamile, izinkinga zokuxhumana, ubunzima bokugxila.

Lesi sifo sikhula isikhathi eside. Izimpawu ze-Alzheimer ziba zimbi kakhulu ngokuya ngeminyaka futhi ekugcineni umuntu akakwazi ukwenza umsebenzi wakhe wansuku zonke. Yize lesi sifo sijwayele ukubonakala kubantu abaneminyaka engaphezu kuka-65, bakhona nalabo abaqala ukugula besebancane. Abanye bangase baphile nalesi sifo iminyaka engu-20, kuyilapho isilinganiso seminyaka yokuphila siyisishiyagalombili.

Lesi sifo kucatshangwa ukuthi isifo sesimanje futhi kulinganiselwa ukuthi sihlasela abantu abayizigidi eziyi-2050 ngo-16.

Yini Ibangela I-Alzheimer's?

Ucwaningo ngezimbangela ze-Alzheimer's, ukuphazamiseka kwengqondo okuwohlokayo, kuyaqhubeka futhi kufundwa izinto ezintsha nsuku zonke. Njengamanje, izimbangela eziyinhloko zokulimala kwe-neuronal ezibonisa lesi sifo zingabonakala. Alukho ulwazi oluningilizayo mayelana nokuthi empeleni kubangelwa yini. Izimbangela ezaziwayo zesifo i-Alzheimer zingabhalwa kanje;

• i-beta-amyloid plaque

Ukugxila okuphezulu kwamaprotheni e-beta-amyloid kubonakala ebuchosheni beziguli eziningi ze-Alzheimer's. Lawa maprotheni aphenduka ama-plaque ezindleleni ze-neuronal, aphazamise ukusebenza kobuchopho.

• Ama-protein node 

Njengoba nje amaprotheni e-beta-amyloid ebuchosheni beziguli ze-Alzheimer ehlangana abe uqwembe, amaprotheni e-tau akha ama-neurofibrillary tangles (NFTs) athinta ukusebenza kobuchopho. Uma i-tau ikhula ibe izinyanda ezinjengezinwele ezibizwa ngokuthi ama-NFT, ivimba uhlelo lokuthutha futhi ivimbele ukukhula kwamaseli. Khona-ke izimpawu ze-synaptic ziyahluleka. I-Tau protein tangles iwuphawu lwesibili lwesifo i-Alzheimer ngakho-ke iyindawo ebalulekile okugxilwe kuyo abacwaningi abafunda lesi sifo.

• I-Glutamate ne-acetylcholine 

Ubuchopho busebenzisa amakhemikhali abizwa ngokuthi ama-neurotransmitters ukuthumela amasignali phakathi kwama-neurons. Uma i-glutamate isebenza ngokweqile, ibeka ingcindezi kuma-neurons anesibopho senkumbulo nokuqonda. Amazinga wokucindezeleka anobuthi asho ukuthi ama-neurons awakwazi ukusebenza kahle noma angasebenzi kahle. I-acetylcholinekungenye i-neurotransmitter ebuchosheni esiza ukufunda nenkumbulo. Lapho umsebenzi we-acetylcholine receptors wehla, ukuzwela kwe-neuronal kuncipha. Lokhu kusho ukuthi ama-neurons abuthaka kakhulu ukuze angatholi amasignali angenayo.

• Ukuvuvukala

Kuyazuzisa lapho ukuvuvukala kuyingxenye yenqubo yokwelapha yemvelo yomzimba. Kodwa lapho izimo ziqala ukudala ukuvuvukala okungapheli, izinkinga ezinkulu zingavela. Ubuchopho obunempilo busebenzisa i-microglia ukuvikela kumagciwane. Uma othile ene-Alzheimer's, ubuchopho bubona ama-tau nodes kanye namaprotheni e-beta-amyloid njengamagciwane, okubangela ukusabela okungapheli kwe-neuro-inflammatory okubangela ukuqhubeka kwe-Alzheimer's.

• izifo ezingamahlalakhona

Ukuvuvukala kuyisici esinomthelela esifweni se-Alzheimer's. Noma yisiphi isifo esidala ukuvuvukala singaba nomthelela ekukhuleni kokuwohloka komqondo noma i-Alzheimer's kubantu asebekhulile. Lezi zifo ezihambisana ne-Alzheimer's zihlanganisa i-herpesvirus yabantu 1 no-2 (HHV-1/2), i-cytomegalovirus (CMV), i-picornavirus, igciwane lesifo sika-Borna, i-chlamydia pneumoniae, Helicobacter pylori, i-Borrelia spirochetes (isifo se-Lyme), i-porphyromonas gingivalis, ne-Treponema. 

Izimpawu ze-Alzheimer's

Isifo i-Alzheimer siyawohloka, okusho ukuthi siba sibi kakhulu ngokuhamba kwesikhathi. Kwenzeka lapho ukuxhumana phakathi kwamangqamuzana obuchopho okuthiwa ama-neurons namanye amangqamuzana obuchopho kulimale. 

Izimpawu ezivame kakhulu ukulahlekelwa inkumbulo nokudideka kwengqondo. Nakuba kukhona ukulahlekelwa inkumbulo okuncane ekuqaleni, izimpawu ezinzima njengokungakwazi ukukhuluma noma ukusabela kwabanye zenzeka ezigabeni zakamuva zesifo. Ezinye izimpawu zesifo i-Alzheimer's yilezi:

• ubunzima bokugxila, 
• Ubunzima bokwenza umsebenzi ojwayelekile 
• Ukudideka
• Ukucindezeleka noma ukukhathazeka ukuqhuma, 
• ukuphazamiseka kwengqondo 
• Ungalahleki kalula
• ukungasebenzi kahle, 
• Ezinye izinkinga ezingokomzimba
• Izinkinga zokuxhumana

Njengoba lesi sifo siqhubeka, abantu baba nenkinga ngamakhono okuxazulula izinkinga, ukugcina umlando wezezimali, nokwenza izinqumo ezibalulekile. Njengoba izimpawu ziba zimbi nakakhulu, iziguli ze-Alzheimer zingase zingawuboni umndeni wazo, zibe nobunzima bokugwinya, zibe nokudideka futhi zidinga ukunakekelwa njalo.

I-Alzheimer's Risk Factors

Umphakathi wezokwelapha ngokuvamile ukholelwa ukuthi isifo i-Alzheimer sibangelwa inhlanganisela yofuzo nezinye izici eziyingozi esikhundleni sembangela eyodwa. Izici eziyingozi zesifo i-Alzheimer zifaka:

• umlando womndeni

Abantu abanesihlobo se-degree yokuqala abane-Alzheimer's banengozi eyengeziwe yalesi sifo.

• ubudala

Ingozi yokuba ne-Alzheimer iphindwe kabili njalo eminyakeni emihlanu ngemva kokuba neminyaka engama-65.

• Ukubhema

Ukubhema kunomthelela ekwakhekeni kokuwohloka komqondo, okuhlanganisa i-Alzheimer's, njengoba kwandisa ukuvuvukala futhi kunciphisa ukugeleza kwegazi emithanjeni.

• Izifo zenhliziyo

emsebenzini wobuchopho, impilo yenhliziyo idlala indima enkulu. Noma yisiphi isimo esilimaza isimiso sokujikeleza kwegazi sandisa ingozi ye-Alzheimer's, okuhlanganisa nesifo senhliziyo, unhlangothi, umfutho wegazi ophakeme, ushukela ophezulu wegazi, i-cholesterol, nezinkinga ze-valve.

• ukulimala kobuchopho okubuhlungu

Ukulimala kobuchopho ngenxa yokulimala kubangela ukungasebenzi kobuchopho nokufa kwamangqamuzana obuchopho, futhi kuyingozi enkulu yesifo i-Alzheimer's.

• Indlela yokuphila engenampilo kanye nokudla okungenamsoco

Abacwaningi babiza i-Alzheimer's njengesifo sesimanje ngenxa yokuthi ukwanda kwalesi sifo kunyukile ngenxa yokudlanga kokudla okungenampilo kwamasiko esimanje.

• izinkinga zokulala

Labo abanezinkinga zokulala zesikhathi eside baye banda ukunqwabelana kwama-beta-amyloid plaques ebuchosheni babo.

• ukumelana ne-insulin

Amaphesenti angamashumi ayisishiyagalombili eziguli ze-Alzheimer's ukumelana ne-insulin noma uhlobo 2 sikashukela unayo. Ukumelana ne-insulin isikhathi eside kungaholela esifweni i-Alzheimer's.

• Ukucindezeleka

Ukucindezeleka isikhathi eside noma okujulile kuyisici esiyingozi se-Alzheimer's. 

• aluminium

I-Aluminium iyinto enobuthi kumaseli ezinzwa futhi engabangela isifo i-Alzheimer's.

• i-testosterone ephansi

Njengoba sikhula, amazinga e-testosterone ayancipha kokubili amadoda nabesifazane. Lokhu kwandisa ingozi yesifo i-Alzheimer's.

Ukwelashwa Kwezifo Ze-Alzheimer

• I-Alzheimer's yisifo esingelapheki. Imithi yokwelapha yamanje yenzelwe ukukhomba izimpawu zesifo kunembangela ewumsuka.
• Ngenxa yokuthi lesi sifo cishe asinaso isizathu esisodwa, ikhambi langempela le-Alzheimer's lingase lingatholakali.
• Abacwaningi bayaqhubeka nokuhlola kokubili ukwelashwa kwe-beta-amyloid kanye ne-tau protein njengendlela yokwelapha engenzeka ye-Alzheimer's.
• Imithi ye-Alzheimer yakhelwe ngokuyinhloko ukuthuthukisa izinga lempilo yeziguli.
• Ngenxa yokuthi ukwelapha kwamanje ngemithi kugxile ezimpawini zesifo i-Alzheimer's, iziguli eziningi ze-Alzheimer nazo zithatha imithi ukuze zilawule ukuziphatha kwazo.
• Lapho amangqamuzana obuchopho ewohloka, kungase kudingeke imithi nezinye izindlela zokwelapha ukulawula ukucasuka, ukukhathazeka, ukucindezeleka, ukuphazamiseka kokulala, ukubona izinto ezingekho, nezinye izinkinga zokuziphatha ze-Alzheimer's.

Yini Elungele Isifo Se-Alzheimer?

Kukhona ukwelashwa kwemvelo okusebenzayo ekudambiseni izimpawu ze-Alzheimer's. Lezi zindlela zokwelapha zikhuthaza impilo enempilo, zivimbela lesi sifo isikhathi eside futhi zivimbele ukuqala kokuwohloka komqondo nokunye ukuphazamiseka kwengqondo.

• umsebenzi womzimba

Ukuzivocavoca kunomthelela omkhulu empilweni yobuchopho. Iziguli ze-Alzheimer ezihamba njalo zenza kangcono emisebenzini kanye ukucindezeleka Izehlakalo zezinye izinkinga zempilo yengqondo, njenge

• umsebenzi wengqondo

Ukuqeqesha ubuchopho kubalulekile njengokusebenza kwemisipha. Ukusebenza kwengqondo okumaphakathi kunciphisa imiphumela yesifo phakathi nokuphila. Labo abanengqondo esebenzayo mancane amathuba okuba babe nesifo i-Alzheimer's.

Imisebenzi yengqondo efana nokudlala imidlalo, ukuxazulula izindida, nokufunda kuyasiza ukuzigcina uqinile njengoba ukhula.

• Vitamin E

Izifundo, Vitamin EImiphumela ikhombisa ukuthi ibambezela i-neurodegeneration ezigulini ezinesifo i-Alzheimer's esimaphakathi kuya kwesinzima. I-Alzheimer's idala ukulimala kwe-oxidative. Ngakho-ke, ama-antioxidants afana ne-vitamin E anamandla okuba ukwelashwa kwalesi sifo.

• Ivithamini D

Ivithamini DIkhiqizwa lapho isikhumba sichayeka ekukhanyeni kwelanga. Isebenza nge-calcium ukwakha amathambo aqinile. Kuyasiza ukulawula amasosha omzimba futhi kubalulekile emjikelezweni wokuphila wamangqamuzana omuntu njengamaseli obuchopho.

Iziguli eziningi ezine-Alzheimer kanye nezinye izifo zokuwohloka komqondo zishoda ngovithamini D. Ukuchayeka ekukhanyeni kwemvelo kukhuthaza ukulala okunempilo, ikakhulukazi ezigulini ezinesifo esinzima se-Alzheimer's.

• I-Melatonin

Ngaphezu kokulala okungcono melatoninInezinzuzo eziningi kulabo abanesifo i-Alzheimer's. Ucwaningo lwakamuva luhlole ukusebenza kwe-melatonin njengokwelapha ukuvimba i-nitric oxide ezigulini ze-Alzheimer's. Iziguli ze-Alzheimer zinomsebenzi ophansi we-melatonin receptors MT1 kanye ne-MT2.

• i-manganese ne-potassium

ukuntuleka kwe-manganese Kuyisici esiyingozi sesifo i-Alzheimer's. Kwanele i-potassium Ngaphandle kwayo, umzimba awukwazi ukucubungula ama-beta-amyloid ngendlela efanele futhi ukwanda kokucindezeleka okwenziwe nge-oxidative nokuvuvukala kubonakala.

Ukwenyuka kwe-potassium ne-magnesium kuthuthukisa ukusebenza kwengqondo futhi kuvimbela ukuqala kwesifo i-Alzheimer's.

• izitshalo zemvelo

Izitshalo zinezinto eziningi zokubuyisela nokuphulukisa. Kunamakhambi athile angashukumisa izinqubo zobuchopho ezidingekayo ukusiza ukuvimbela isifo i-Alzheimer's.

liqhakaze ve turmerickuye kwaphawulwa ukuthi kunemiphumela enenzuzo ezigulini ze-Alzheimer's. Ngenxa yezindawo zayo zokulwa nokuvuvukala kanye ne-antioxidant, i-curcumin ithuthukisa umsebenzi wokuqonda ngokunciphisa ukwakheka kwama-beta-amyloid plaques.

• i-ketosis

I-Ketosis ukusetshenziswa kwamafutha agciniwe ukuze uthole amandla. Lapho umzimba unikezwa ama-ketone afanelekile, njenge-medium-chain triglycerides etholakala emafutheni kakhukhunathi, iziguli ze-Alzheimer zingathuthukisa ukusebenza kwazo kwenkumbulo.

Ukukhuthaza i-ketosis, ukukhuthaza umzimba ukuthi usebenzise amafutha esikhundleni se-glucose ukuzila ukudla ngezikhathi ezithile kanye nama-carbohydrate aphansi Ukudla kwe-ketogenic esebenzayo. Uma uku-ketosis, umzimba udala ingcindezi encane ye-oxidative futhi unikeze amandla e-mitochondrial asebenza kahle ebuchosheni. Le nqubo inciphisa amazinga e-glutamate futhi ikhuthaze ukusebenza kobuchopho obunempilo.

• amafutha omnqumo

Ukusebenzisa amafutha omnqumo njengokudla Ukudla kwaseMeditheraibonise imiphumela enenzuzo ezigulini ze-Alzheimer's. Ekuhlolweni kwezilwane, amafutha omnqumo athuthukisa inkumbulo futhi akhuthaza ukukhula kwamangqamuzana amasha. amafutha omnqumoNjengoba isebenza ukunciphisa ukwakheka kwe-beta-amyloid plaque, ingabambezela futhi ivimbele ukuqala kwesifo i-Alzheimer's.

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