Yintoni isifo sika-Addison, kutheni isenzeka? Iimpawu kunye noNyango

Amadlala eadrenal abekwe ngaphezulu kwezintso. La madlala avelisa uninzi lweehomoni ezifunwa ngumzimba kwimisebenzi eqhelekileyo.

Isifo sika-AddisonKwenzeka xa i-adrenal cortex yonakalisiwe kwaye i-adrenal glands ayivelisi ngokwaneleyo i-hormone ye-steroid i-cortisol kunye ne-aldosterone.

icortisolilawula ukuphendula komzimba kwiimeko ezixinzelelekileyo. I-Aldosterone inceda ukulawula i-sodium kunye ne-potassium. I-adrenal cortex ikwavelisa iihomoni zesini (androgens).

Yintoni Addison?

Isifo sika-AddisonKwenzeka xa amadlala eadrenal yomntu engavelisi amanqanaba aphezulu ngokwaneleyo eehomoni ezininzi ezibalulekileyo, kubandakanya icortisol kwaye ngamanye amaxesha ialdosterone.ukungasebenzi kakuhle kweadrenaline” lelinye igama lemeko ebizwa

Amadlala eadrenal abekwe ngaphezulu nje kwezintso kwaye anendima ebalulekileyo ekuveliseni iihomoni ezinjenge-adrenaline kunye ne-corticosteroids, enemisebenzi emininzi ngamaxesha oxinzelelo olubukhali kunye nokuphila nje kwemihla ngemihla. 

Ezi hormone ziyimfuneko ukugcina i-homeostasis kwaye ithumele "imiyalelo" kumalungu kunye nezicubu emzimbeni. Isifo sika-AddisonIiHormones ezichatshazelwa yihomoni yegilo ziquka iglucocorticoids (efana ne-cortisol), i-mineralocorticoids (kuquka i-aldosterone), kunye ne-androgens (ihomoni zesini zamadoda).

Nangona le meko inokubeka ubomi esichengeni kwezinye iimeko, iimpawu zinokulawulwa ngonyango lokubuyisela ihomoni.

Iimbangela zeZifo ze-Addison

Ukuphazamiseka kwe-adrenal gland

Ukuphazamiseka kwimveliso yehomoni kwi-adrenal glands Isifo sika-Addisoniyabangela. Oku konakala kunokubangelwa liqela lezinto, eziquka ingxaki yokuzikhusela komzimba, isifo sephepha, okanye isiphene semfuza.

Nangona kunjalo, malunga neepesenti ze-80 zeemeko ezininzi ze-Addison's disease ngenxa yeemeko ze-autoimmune.

Amadlala eadrenal ayayeka ukuvelisa iihomoni ze-steroid ezaneleyo (i-cortisol kunye ne-aldosterone) xa i-90 pesenti ye-adrenal cortex itshatyalaliswa.

Ngokukhawuleza xa amanqanaba ezi hormone eqala ukwehla, Iimpawu kunye neempawu zesifo sika-Addison iqala ukuvela.

iimeko ze-autoimmune

Amajoni omzimba yindlela yokuzikhusela komzimba kwizifo, iityhefu, okanye usulelo. Xa umntu egula, amajoni akhe omzimba avelisa izilwa-buhlungu ezihlasela nantoni na ebangela ukuba agule.

Abanye abantu amajoni omzimba anokuqalisa ukuhlasela izihlunu kunye namalungu asempilweni – oku ukuphazamiseka kwe-autoimmune Kubizwa.

Isifo sika-Addison Kule meko, i-immune system ihlasela iiseli ze-adrenal glands, zinciphisa kancane umsebenzi wazo.

isiphumo semeko ye-autoimmune Isifo sika-Addison, isifo sika-autoimmune Addison Kwakhona kuthiwa.

Iimbangela zeGenetic ze-Autoimmune Addison's Disease

Uphando lwakutsha nje lubonise ukuba abanye abantu abaneemfuza ezithile banokuthi babe nemeko ye-autoimmune.

Isifo sika-AddisonNangona i-genetics yemeko ingaqondwa ngokupheleleyo, i-genes edla ngokunxulunyaniswa nale meko yeyosapho lwemfuza ebizwa ngokuba yi-human leukocyte antigen (HLA) complex.

Olu bunzima lunceda amajoni omzimba ukuba ahlule phakathi kweeproteni zomzimba kunye nezo zenziwe ziintsholongwane kunye neebhaktheriya.

Isifo sika-Autoimmune Addison izigulane ezininzi hypothyroidism, uhlobo 1 seswekile okanye ube nesinye isifo se-autoimmune, esifana ne-vitiligo.

Isifo sephepha

Isifo sephepha (TB) lusulelo olubangelwa yintsholongwane oluchaphazela imiphunga kwaye lunokunwenwela kwamanye amalungu omzimba. Ukuba i-TB ifikelela kumadlala eadrenal, inokuwonzakalisa kakhulu kwaye ichaphazele ukuveliswa kwehomoni.

Izigulane zeSifo sephepha zinomngcipheko ophezulu wokulimala kwi-adrenal glands, oku kuthetha ukuba yabo Isifo sika-Addison kwandisa amathuba ophuhliso.

Ekubeni isifo sephepha sinqabile ngoku, unobangela wale meko Isifo sika-Addison iimeko nazo zinqabile. Nangona kunjalo, kukho amazinga aphezulu kumazwe apho i-TB iyingxaki enkulu.

Ezinye izizathu

Isifo sika-Addison, inokubangelwa zezinye izinto ezichaphazela i-adrenal glands:

Isiphene sofuzo apho i-adrenal glands ayiphuhli kakuhle

– ukopha

- Adrenalectomy - ukususwa ngotyando kwamadlala adrenal

- Amyloidosis

usulelo olufana ne-HIV okanye usulelo oluqhelekileyo lwegwele

– Umhlaza oye wanemetastasized kumadlala eadrenal

Ukungaphumeleli kwe-adrenal yesibini

Ukuba idlala lengqula liyagula, amadlala eadrenal nawo anokuchaphazeleka kakubi. Ngokuqhelekileyo, i-pituitary ivelisa ihomoni ye-adrenocorticotropic (ACTH). Le hormone ivuselela i-adrenal glands ukuvelisa amahomoni.

Ukuba i-pituitary yonakalisiwe okanye inesifo, i-ACTH encinci iyaveliswa kwaye, ngenxa yoko, i-hormone encinci iveliswa ngamadlala e-adrenal, nokuba awanaso isifo. Oku kubizwa ngokuba yi-secondary adrenal insufficiency.

Iisteroids

Abanye abantu bathatha i-anabolic steroids, njengabakhi bomzimba, Isifo sika-Addison umngcipheko uphezulu. Ukuveliswa kwehomoni, ngakumbi okubangelwa kukusebenzisa ii-steroids ixesha elide, kunokuphazamisa amandla e-adrenal glands ukuvelisa amanqanaba ehomoni enempilo - oku kunokonyusa umngcipheko wokuba sisifo.

IiGlucocorticoids ezifana ne-cortisone, i-hydrocortisone, i-prednisone, i-prednisolone, kunye ne-dexamethasone zisebenza njenge-cortisol. Ngamanye amazwi, umzimba ukholelwa ukuba kukho ukwanda kwe-cortisol kwaye icinezela i-ACTH.

Njengoko kukhankanyiwe ngasentla, ukuhla kwe-ACTH kubangela ukuba iihomoni ezincinci ziveliswe ngamadlala eadrenal.

Kwakhona, lupus Abantu abathatha i-corticosteroids yomlomo kwiimeko ezifana nesifo sesibindi sokukrala okanye isifo sesibindi esivuthayo kwaye ngokukhawuleza bayeke ukuyeka banokufumana ukusilela kwe-adrenal yesibini.

Ziziphi iimpawu ze-Addison's Disease?

Isifo sika-Addison Abantu abane-dandruff banokuba nezi mpawu zilandelayo:

– ubuthathaka kwezihlunu

– Ubuthathaka kunye nokudinwa

– Ukwenziwa mnyama kombala wolusu

- Ukunciphisa umzimba okanye ukunciphisa ukutya

-Ukunciphisa izinga lentliziyo okanye uxinzelelo lwegazi

– Amanqanaba eswekile ephantsi

– Izilonda emlonyeni

– Ukuthanda ityuwa

- Isicaphucaphu

– ukugabha

Isifo sika-Addison Abantu abaphila nale meko banokufumana iimpawu ze-neuropsychiatric ezifana nezi:

– Ukucaphuka okanye ukudakumba

– Amandla aphantsi

- Ukuphazamiseka kokulala

Isifo sika-Addison ukuba ayiphathwa ixesha elide, Ingxaki yaseAddisonian iya kuba. Ingxaki yaseAddisonianIimpawu ezinxulumene nayo zezi:

-Inkxalabo kunye noxinzelelo

– delirium

-Imibono yokubona kunye nokuva

enganyangwanga Ingxaki yaseAddisonian kunokubangela umothuko nokufa.

Ngubani osemngciphekweni weSifo i-Addison?

Abantu abakwezi meko zilandelayo: Isifo sika-Addison basemngciphekweni omkhulu wokuba:

– Abo banomhlaza

-Iindawo ze-Anticoagulant (izinciphisi zegazi)

– Abo banezifo ezingapheliyo ezifana nesifo sephepha

– Abo benza utyando lokususa nayiphi na indawo ye-adrenal gland

– Abo banezifo ezizimelayo ezifana nohlobo loku-1 lweswekile okanye isifo seGraves

Sifunyaniswa njani isifo sika-Addison?

Ugqirha uya kubuza malunga nembali yonyango kunye neempawu. Uya kwenza uvavanyo lomzimba kwaye ayalele iimvavanyo zaselebhu ukujonga amanqanaba e-potassium kunye nesodium.

Ugqirha unokuyalela iimvavanyo zemifanekiso kwaye alinganise inqanaba lehomoni.

Unyango lwe-Addison's Disease

Unyango lwesifo luya kuxhomekeka kwinto ebangela imeko. Ugqirha unokumisela iziyobisi ezilawula i-adrenal glands.

Kubaluleke kakhulu ukulandela isicwangciso sonyango esenziwe ngugqirha. enganyangwa Isifo sika-Addison, Ingxaki yaseAddisonianyintoni enokukhokelela.

Ukuba imeko ayizange iphathwe ixesha elide kwaye Ingxaki yaseAddisonian Ukuba iye yaqhubela phambili kwimeko ebeka ubomi esichengeni ebizwa

Ingxaki yaseAddisoniankubangela uxinzelelo lwegazi oluphantsi, i-potassium ephezulu kunye namaqondo aphantsi eswekile egazini.

Amayeza

Kusenokuba yimfuneko ukusebenzisa indibaniselwano yeziyobisi zeglucocorticoid (iziyobisi ezichasayo) ukunyanga eso sifo. La machiza aya kuthathwa ubomi bonke.

Ukutshintshwa kwehomoni kunokwenziwa endaweni yehomoni ezingayenziyo idlala lengqula.

Unyango lweNdalo lweSifo se-Addison

dla ityuwa eyaneleyo

Isifo sika-Addisonkunokubangela amanqanaba aphantsi e-aldosterone, okwandisa imfuno yetyuwa. Zama ukufumana iimfuno zakho zetyuwa ezongeziweyo ekutyeni okunempilo okufana nomhluzi kunye netyuwa yolwandle.

Thatha i-calcium kunye ne-vitamin D

Ukuthatha amayeza e-corticosteroid kuye kwadibaniswa nomngcipheko ophezulu we-osteoporosis kunye nokulahlekelwa kwamathambo, okungonelanga. calcium kwaye kuthetha ukuba ukusebenzisa i-vitamin D kubaluleke kakhulu ekugcineni impilo yamathambo. 

Ukutya kwe-calcium kunokunyuswa ngokutya iimveliso zobisi ezifana nobisi olukrwada, iyogathi, i-kefir kunye netshizi ebilisiweyo, imifuno eluhlaza efana nekhaphetshu kunye ne-broccoli, kunye nokutya okuphezulu kwe-calcium njengesardadi, iimbotyi kunye neealmonds.

Ivithamin D Eyona ndlela yokunyusa amanqanaba akho ngokwemvelo kukuchitha ixesha elangeni yonke imihla ulusu luveziwe.

Thatha i-anti-inflammatory diet

Ukutya / iziselo ukunciphisa okanye ukunqanda ukuxhasa amajoni omzimba kubandakanya:

Utywala obuninzi okanye i-caffeine, enokuphazamisa umjikelo wokulala kwaye ibangele ukuxhalaba okanye ukudandatheka

Uninzi lwemithombo yeswekile kunye ne-sweeteners (kubandakanya isiraphu yengqolowa ye-fructose ephezulu, iilekese ezipakishweyo, kunye neenkozo ezisulungekileyo)

-Kuphephe ukutya okupakishwe kunye nokucutshungulwa kangangoko kunokwenzeka ngenxa yokuba ziqulethe iintlobo ezininzi zezithako ezenziweyo, izigcina-mpahla, iswekile, njl.

-I-oyile yemifuno ene-Hydrogenated kunye nesulungekileyo (iimbotyi zesoya, i-canola, i-safflower, ujongilanga kunye nombona)

Zimisele ngokutya kwendalo, okungacocwanga xa kunokwenzeka. Olunye ukhetho olungcono olubandakanyiweyo kwi-anti-inflammatory diet ziquka:

– Ioyile yendalo, esempilweni (umz. ioyile yomnquma)

-Imifuno eninzi (ingakumbi yonke imifuno enamagqabi kunye nemifuno ye-cruciferous efana ne-cauliflower, i-broccoli, i-Brussels sprouts)

-Intlanzi yasendle (efana ne-salmon, i-mackerel okanye i-sardines, ebonelela nge-anti-inflammatory omega-3 fatty acids)

– Iimveliso zezilwanyana ezikumgangatho ophezulu ezityiswa ingca, idlelo kunye ne-organic (umzekelo, amaqanda, inyama yenkomo, inkukhu kunye ne-turkey)

-Imifuno yolwandle efana ne-seaweed (ixabiso eliphezulu le-iodine ukuxhasa impilo ye-thyroid)

-Ityuwa yolwandle iCeltic okanye iHimalayan

Ukutya okunefayibha ephezulu okufana namaqunube, imbewu ye-chia, imbewu yeflakisi, kunye nemifuno enesitatshi

Ukutya okuneProbiotic okunje ngekombucha, sauerkraut, iyogathi kunye nekefir

-Ijinja, i-turmeric, iparsley, njl. imifuno kunye neziqholo

lawula uxinzelelo

Fumana ubuthongo obusemgangathweni kwaye uphumle ngokwaneleyo. Jonga iiyure ezisibhozo ukuya kwezili-10 zokulala ubusuku ngabunye, kuxhomekeke kwiimfuno zakho ezithile.

Ezinye iindlela zokunceda ukulawula uxinzelelo ziquka:

-Ukwenza izinto ozithandayo okanye into eyonwabisayo yonke imihla

– ukucamngca 

-Iendlela zokuphefumla eziphumlayo

-Ukuchitha ixesha ngaphandle, ekukhanyeni kwelanga nakwindalo

– Ukugcina ishedyuli yomsebenzi engaguqukiyo nefanelekileyo

-Ukutya ngeshedyuli eqhelekileyo kunye nokuphepha izinto ezininzi ezivuselelayo ezifana notywala, iswekile kunye necaffeine

-Funa uncedo lwengcali xa lufuneka ukujongana neziganeko ezibalulekileyo zobomi okanye umonzakalo

Izongezo ezixhasa impendulo yoxinzelelo

Ezinye izongezo zinokunceda ukuxhasa amajoni omzimba kunye nokumelana noxinzelelo. Imizekelo enokusebenza yile:

-Amakhowa amayeza afana nereishi kunye ne-cordyceps

-Amayeza e-Adaptogen afana ne-ashwagandha kunye ne-astragalus

- iginseng

-Magnesium

-Omega-3 fatty acids

- Kanye kunye ne-probiotic supplement, ukuthatha i-multivitamin esemgangathweni ebonelela ngeevithamini ze-B, i-vitamin D, kunye ne-calcium nayo inokuxhasa impilo yamathumbu kunye nokukhusela ekunqongopheni kwezondlo.

Kwenzeka ntoni ukuba isifo sika-Addison asinyangwa?

Ubume ingxaki yeadrenalUkuba iqhubela phambili kwaye ayiphathwa, abantu banokufumana iimpawu ezinzima baze bafe ngokukhawuleza, ngoko ke le nto kufuneka ithathelwe ingqalelo kakhulu.

ingxaki yeadrenal ukungenelela ngokuqhelekileyo kubandakanya i-injection ye-high-dose steroids, i-fluid, kunye ne-electrolytes ukunceda ukubuyisela ukusebenza kwe-adrenal kunye ne-pituitary glands.

Isifo sika-Addison Ingaba uyaphila? Ungashiya uluvo.