Iimpawu ze-Alzheimer's-Yintoni elungile kwi-Alzheimer's Disease?

Isifo sika-Alzheimer lolona hlobo luxhaphakileyo lwe-dementia. Esi sifo sibangela iingxaki kubuchule bobuchopho bokukhumbula, ukucinga, nokwenza ngokufanelekileyo. Iimpawu ze-Alzheimer's ziquka ukudideka, ubunzima bokwenza imisebenzi eqhelekileyo, iingxaki zonxibelelwano, ubunzima bokugxila.

Esi sifo sikhula ixesha elide. Iimpawu ze-Alzheimer ziya ziba mandundu ngokuhamba kweminyaka kwaye umntu akakwazi ukwenza umsebenzi wakhe wemihla ngemihla. Nangona esi sifo siqhele ukubonwa kubantu abangaphezulu kweminyaka engama-65, bakho nabo bathi baphuhle esi sifo besebancinane. Abanye banokuphila nesi sifo ixesha elide ukuya kutsho kwiminyaka engama-20, ngelixa umndilili wobomi obuqhelekileyo busibhozo.

Esi sifo sicingelwa ukuba sisifo sanamhlanje kwaye kuqikelelwa ukuba sichaphazela abantu abazizigidi ezili-2050 ngo-16.

Yintoni ebangela isifo sika-Alzheimer?

Izifundo ngezizathu ze-Alzheimer's, ukuphazamiseka kwengqondo okuwohlokayo, kuyaqhubeka kwaye izinto ezintsha zifundwa yonke imihla. Okwangoku, kuphela izizathu ezisisiseko zomonakalo we-neuronal obonisa isifo unokuchongwa. Akukho lwazi lubanzi malunga nokuba yintoni kanye kanye eyibangelayo. Izizathu ezaziwayo zesifo sika-Alzheimer zingadweliswa ngolu hlobo lulandelayo;

• i-beta-amyloid plaque

Uxinzelelo oluphezulu lweeproteni ze-beta-amyloid zibonwa kwingqondo yezigulane ezininzi ze-Alzheimer. Ezi proteni zijika zibe ngamacwecwe kwiindlela ze-neuronal, ziphazamisa ukusebenza kwengqondo.

• Tau protein nodes 

Kanye njengokuba iiproteni ze-beta-amyloid kwiingqondo zezigulane ze-Alzheimer zidibana kwi-plaque, iiprotheyini ze-tau zenza i-neurofibrillary tangles (NFTs) ezichaphazela ukusebenza kwengqondo. Xa i-tau ikhula ibe yimiqulu efana neenwele ezibizwa ngokuba yi-NFTs, ithintela inkqubo yothutho kwaye inqanda ukukhula kweeseli. Emva koko iimpawu ze-synaptic ziyasilela. I-Tau protein tangles luphawu lwesibini lwesifo se-Alzheimer kwaye ke yindawo ebalulekileyo yokugxila kubaphandi abafunda esi sifo.

• Glutamate kunye ne-acetylcholine 

Ingqondo isebenzisa iikhemikhali ezibizwa ngokuba zii-neurotransmitters ukuthumela imiqondiso phakathi kwee-neuron. Xa i-glutamate isebenza ngokugqithiseleyo, ibeka uxinzelelo kwi-neurons ejongene nememori kunye nokuqonda. Amanqanaba oxinzelelo oluyityhefu athetha ukuba i-neurons ayikwazi ukusebenza ngokufanelekileyo okanye ingasebenzi kakuhle. IAcetylcholineyenye i-neurotransmitter ebuchotsheni enceda ukufunda kunye nenkumbulo. Xa umsebenzi we-acetylcholine receptors uyancipha, i-neuronal sensitivity iyancipha. Oku kuthetha ukuba ii-neurons zibuthathaka kakhulu ukuba zingafumana imiqondiso engenayo.

• Ukudumba

Kuluncedo xa ukudumba kuyinxalenye yenkqubo yokuphilisa yendalo yomzimba. Kodwa xa iimeko ziqala ukudala ukuvutha okungapheliyo, iingxaki ezinzulu zinokuvela. Ingqondo ephilileyo isebenzisa i-microglia ukukhusela kwiintsholongwane. Xa umntu ene-Alzheimer's, ingqondo ibona ii-tau nodes kunye ne-beta-amyloid proteins njenge-pathogens, ibangela ukusabela okungapheliyo kwe-neuro-inflammatory enoxanduva lokuqhubela phambili kwe-Alzheimer.

• usulelo olungapheliyo

Ukudumba kungumba onegalelo kwisifo sika-Alzheimer. Nasiphi na isifo esibangela ukudumba sinokuba negalelo ekuphuhlisweni kwe-dementia okanye i-Alzheimer's kubantu abadala. Ezi zifo ezinxulumene ne-Alzheimer ziquka i-herpesviruses yabantu 1 kunye ne-2 (HHV-1 / 2), i-cytomegalovirus (CMV), i-picornavirus, intsholongwane yesifo sikaBorna, i-chlamydia pneumoniae, Helicobacter pylori, i-Borrelia spirochetes (isifo seLyme), i-porphyromonas gingivalis, kunye ne-Treponema. 

Iimpawu ze-Alzheimer's

Isifo sika-Alzheimer siyawohloka, nto leyo ethetha ukuba siya siba mandundu ngokuhamba kwexesha. Kwenzeka xa unxibelelwano phakathi kweeseli zengqondo ezibizwa ngokuba zii-neurons kunye nezinye iiseli zengqondo zonakaliswe. 

Ezona mpawu zixhaphakileyo kukulahlekelwa yinkumbulo kunye nokubhideka kwengqondo. Nangona kukho ukulahleka kwememori encinci kwinqanaba lokuqala, iimpawu ezinzima ezifana nokungakwazi ukuthetha okanye ukusabela kwabanye kwenzeka kwizigaba zokugqibela zesifo. Ezinye iimpawu zesifo sika-Alzheimer zezi:

• ubunzima bokugxila, 
• Ubunzima bokwenza umsebenzi oqhelekileyo 
• Ukubhideka
• Uxinzelelo okanye ixhala ukudubula, 
• ukuphazamiseka kwengqondo 
• Musa ukulahleka lula
• ulungelelaniso olulambathayo, 
• Ezinye iingxaki zomzimba
• Imiba yonxibelelwano

Njengoko isifo siqhubela phambili, abantu baneengxaki kwizakhono zokusombulula iingxaki, ukugcina umkhondo wemali, kunye nokwenza izigqibo ezibalulekileyo. Njengoko iimpawu zisiya ziba mandundu, izigulane ezine-Alzheimer zisenokungaziqondi iintsapho zazo, zibe nobunzima bokuginya, zibe nexhala kwaye zifuna ukukhathalelwa rhoqo.

I-Alzheimer's Risk Factors

Uluntu lwezonyango ngokubanzi lukholelwa ukuba isifo se-Alzheimer sibangelwa yindibaniselwano yemfuza kunye nezinye izinto ezinobungozi kunokuba kube ngunobangela omnye. Izinto ezinobungozi kwisifo se-Alzheimer ziquka:

• imbali yosapho

Abantu abanesihlobo sokuqala abane-Alzheimer banomngcipheko owongeziweyo wesi sifo.

• yobudala

Umngcipheko wokuphuhlisa i-Alzheimer uphindwe kabini emva kweminyaka emihlanu emva kokuguqula i-65.

• Ukutshaya

Ukutshaya icuba kunegalelo ekukhuleni kwesifo sengqondo esiyingozi, kuquka i-Alzheimer's, njengoko kwandisa ukudumba kunye nokunciphisa ukuhamba kwegazi emithanjeni.

• Izifo zentliziyo

ekusebenzeni kwengqondo, impilo yentliziyo idlala indima enkulu. Nayiphi na imeko eyonakalisa inkqubo yokujikeleza kwegazi kwandisa umngcipheko we-Alzheimer, kuquka nesifo sentliziyo, isifo sohlangothi, uxinzelelo lwegazi oluphezulu, iswekile yegazi ephezulu, i-cholesterol, kunye neengxaki zevalve.

• ukwenzakala kwengqondo ebuhlungu

Ukonakala kwengqondo ngenxa yokwenzakala kubangela ukungasebenzi kakuhle kwengqondo kunye nokufa kweeseli zengqondo, kwaye ngumngcipheko omkhulu wesifo i-Alzheimer's.

• Indlela yokuphila engafanelekanga kunye nokutya okungafanelekanga

Abaphandi babiza i-Alzheimer's isifo sanamhlanje kuba ukuxhaphaka kwesi sifo kuye kwanda ngokuxhaphaka kokutya okungenampilo kwiinkcubeko zanamhlanje.

• iingxaki zokulala

Abo baneengxaki zokulala ixesha elide baye bandisa ukuqokelelana kwee-beta-amyloid plaques ebuchotsheni babo.

• ukumelana ne-insulin

Amashumi asibhozo ekhulwini ezigulane ze-Alzheimer ukumelana ne-insulin okanye uhlobo 2 seswekile uye. Ukunganyangeki kwe-insulin ixesha elide kunokukhokelela kwisifo sika-Alzheimer.

• uxinzelelo

Uxinzelelo olude okanye olunzulu luyingozi kwi-Alzheimer's. 

• aluminium

Ialuminiyam yinto eyityhefu kwiiseli zemithambo-luvo kwaye inokubangela isifo sika-Alzheimer.

• testosterone ephantsi

Njengoko sikhula, amanqanaba e-testosterone ayancipha kumadoda kunye nabasetyhini. Oku kwandisa umngcipheko wesifo sika-Alzheimer.

Unyango lwe-Alzheimer's Disease

• I-Alzheimer sisifo esinganyangekiyo. Unyango lwangoku lwamayeza lwenzelwe ukujolisa kwiimpawu zesifo kunokuba unobangela osisiseko.
• Ngenxa yokuba esi sifo mhlawumbi asinasizathu esinye, iyeza lokwenyani le-Alzheimer's lisenokungafunyanwa.
• Abaphandi bayaqhubeka nokuphonononga zombini i-beta-amyloid kunye ne-tau protein yonyango njengonyango olunokwenzeka lwe-Alzheimer's.
• Amachiza e-Alzheimer enzelwe ikakhulu ukuphucula umgangatho wobomi bezigulane.
• Ngenxa yokuba unyango lwangoku lwamayeza lugxininisa kwiimpawu zesifo sika-Alzheimer, izigulane ezininzi ze-Alzheimer nazo zithatha amayeza ukulawula ukuziphatha kwazo.
• Xa iiseli zobuchopho ziwohloka, kusenokufuneka amayeza nolunye unyango ukuze kuthintelwe ukucaphuka, ukuxhalaba, ukudandatheka, ukungalali kakuhle, ukubona izinto ezingekhoyo, nezinye iingxaki zokuziphatha ze-Alzheimer's.

Yintoni Elungileyo kwiSifo sika-Alzheimer?

Kukho unyango lwendalo olusebenzayo ekudambiseni iimpawu ze-Alzheimer. Olu nyango lukhuthaza ubomi obunempilo, luthintela isifo ixesha elide kwaye luthintele ukuqala kwesifo sengqondo esiyingozi kunye nezinye iingxaki zengqondo.

• umsebenzi womzimba

Ukuzilolonga kunempembelelo enkulu kwimpilo yengqondo. Izigulane ze-Alzheimer ezihamba rhoqo zenza ngcono kwimisebenzi kunye ukudakumba Izehlo zezinye iingxaki zempilo yengqondo, ezifana

• umsebenzi wengqondo

Ukuqeqesha ingqondo kubaluleke ngokufanayo nokusebenza kwezihlunu. Umsebenzi wengqondo ophakathi kunciphisa imiphumo yesifo kwi-midlife. Abo banengqondo esebenzayo abanakufane babe nesifo sika-Alzheimer.

Imisebenzi yengqondo enjengokudlala imidlalo, ukusombulula iipuzzle, kunye nokufunda inceda ukuba uhlale usempilweni njengoko ukhula.

• Ivithamin E

Izifundo, Ivithamin EIziphumo zibonisa ukuba iyacothisa i-neurodegeneration kwizigulane ezine-moderate ukuya kwi-Alzheimer's disease. I-Alzheimer ibangela umonakalo oxidative. Ke ngoko, i-antioxidants efana ne-vitamin E inamandla okuba lunyango lwesi sifo.

• Ivithamin D

Ivithamin DIveliswa xa ulusu luchanekile ekukhanyeni kwelanga. Isebenza kunye ne-calcium ukwakha amathambo aqinileyo. Inceda ukulawula amajoni omzimba kwaye ibalulekile kumjikelo wobomi beeseli zomntu ezifana neeseli zengqondo.

Izigulana ezininzi ezine-Alzheimer's kunye nezinye izifo zengqondo zinqongophele kwi-vitamin D. Ukubonakaliswa kokukhanya kwendalo kukhuthaza ukulala okunempilo, ngakumbi kwizigulane ezine-Alzheimer's disease.

• Melatonin

Ukongeza kokulala okungcono melatoninIneenzuzo ezininzi kwabo banesifo sika-Alzheimer. Uphononongo lwakutsha nje luvavanye ukusebenza kwe-melatonin njengonyango lokuthintela i-nitric oxide kwizigulane ze-Alzheimer. Izigulane ze-Alzheimer zinomsebenzi ophantsi we-melatonin receptors MT1 kunye ne-MT2.

• manganese kunye ne potassium

ukunqongophala kwemanganese Kungumngcipheko wesifo sika-Alzheimer. Kwanele potassium Ngaphandle kwayo, umzimba awukwazi ukwenza i-beta-amyloids ngokufanelekileyo kwaye ukwanda koxinzelelo lwe-oxidative kunye nokuvuvukala kubonakala.

Ukwandisa i-potassium kunye ne-magnesium intake kuphucula ukusebenza kwengqondo kunye nokuthintela ukuqala kwesifo se-Alzheimer.

• izityalo zendalo

Izityalo zineempawu ezininzi zokubuyisela nokuphilisa. Kukho imifuno ethile enokuvuselela iinkqubo zobuchopho eziyimfuneko ukunceda ukukhusela isifo se-Alzheimer.

nesafron ve I-turmerickuye kwabonwa ukuba kuneziphumo eziluncedo kwizigulana ze-Alzheimer. Ngenxa yezinto ezichasayo kunye ne-antioxidant, i-curcumin iphucula umsebenzi wokuqonda ngokunciphisa ukubunjwa kwamacwecwe e-beta-amyloid.

• ketosis

I-Ketosis kukusetyenziswa kwamafutha agciniweyo ukwenzela amandla. Xa umzimba unikezelwa ngeetoni ezifanelekileyo, ezifana ne-medium-chain triglycerides efunyenwe kwioli yekakhukhunathi, izigulane ze-Alzheimer zinokuphucula umsebenzi wazo wememori.

Ukukhuthaza i-ketosis, ukukhuthaza umzimba ukuba usebenzise amafutha endaweni yeglucose ukuzila ukutya okwethutyana kunye ne-carbohydrates ephantsi ukutya kwe ketogenic esebenzayo. Xa kwi-ketosis, umzimba udala uxinzelelo oluncinci lwe-oxidative kwaye unikeze amandla asebenzayo e-mitochondrial kwingqondo. Le nkqubo inciphisa amanqanaba e-glutamate kwaye ikhuthaza ukusebenza kwengqondo enempilo.

• namafutha omnquma

Ukusebenzisa ioli yomnquma njengokutya Ukutya kweMediteraubonise iziphumo eziluncedo kwizigulane ze-Alzheimer. Kuvavanyo lwezilwanyana, ioli yomnquma yayiphucula inkumbulo kwaye yakhuthaza ukukhula kweeseli ezintsha. namafutha omnqumaEkubeni yenza ukunciphisa ukubunjwa kwe-beta-amyloid plaque, inokulibazisa kwaye ithintele ukuqala kwesifo se-Alzheimer.

Umthombo: 1, 2