Matšoao a Alzheimer - Ke Eng e Molemo Bakeng sa Lefu la Alzheimer?

Lefu la Alzheimer ke mofuta o atileng haholo oa 'dementia'. Boloetse bona bo baka mathata ka bokhoni ba boko ba ho hopola, ho nahana le ho etsa lintho ka nepo. Matšoao a lefu la Alzheimer a kenyelletsa pherekano, bothata ba ho etsa mesebetsi e tloaelehileng, mathata a puisano, bothata ba ho tsepamisa maikutlo.

Lefu lena le hlaha ka nako e telele. Matšoao a Alzheimer a mpefala le botsofali mme qetellong motho ha a khone ho etsa mosebetsi oa hae oa letsatsi le letsatsi. Le hoja hangata lefu lena le bonoa ho batho ba ka holimo ho lilemo tse 65, ho boetse ho na le ba tšoaroang ke lefu lena ba sa le banyenyane. Ba bang ba ka ’na ba phela le lefu lena ho fihlela lilemo tse 20, ha karolelano ea nako ea bophelo e le robeli.

Ho nahanoa hore lefu lena ke lefu la mehleng ea kajeno 'me ho hakanngoa hore le tla tšoara batho ba limilione tse 2050 ka 16.

Lefu la Alzheimer le Baka'ng?

Lithuto tse mabapi le lisosa tsa Alzheimer's, lefu la boko le senyehang, li tsoela pele 'me ho ithutoa lintho tse ncha letsatsi le leng le le leng. Hona joale, ke lisosa tse ka sehloohong tsa tšenyo ea neuronal e khethollang lefu lena e ka tsejoang. Ha ho na boitsebiso bo felletseng ba hore na ha e le hantle bo bakoa ke eng. Lisosa tse tsebahalang tsa lefu la Alzheimer li ka thathamisoa ka tsela e latelang;

• letlapa la beta-amyloid

Maemo a phahameng a liprotheine tsa beta-amyloid a bonoa bokong ba bakuli ba bangata ba Alzheimer. Liprotheine tsena li fetoha li-plaque litseleng tsa neuronal, tse sitisang tšebetso ea boko.

• Li-node tsa protheine 

Joalo ka ha liprotheine tsa beta-amyloid bokong ba bakuli ba lefu la Alzheimer li bokellana ho ba plaque, liprotheine tsa tau li theha li-neurofibrillary tangles (NFTs) tse amang tšebetso ea boko. Ha tau e fetoha dingata tse kang moriri tse bitsoang NFTs, e thibela tsamaiso ea lipalangoang le ho thibela kholo ea lisele. Ebe matšoao a synaptic a hloleha. Tau protein tangles ke lets'oao la bobeli la lefu la Alzheimer's mme ka hona ke sebaka sa bohlokoa sa bafuputsi ba ithutang lefu lena.

• Glutamate le acetylcholine 

Boko bo sebelisa lik'hemik'hale tse bitsoang li-neurotransmitters ho romela melaetsa pakeng tsa methapo ea kutlo. Ha glutamate e sebetsa ho feta tekano, e beha khatello ho li-neurone tse ikarabellang bakeng sa mohopolo le temoho. Maemo a khatello ea kelello a chefo a bolela hore li-neurone ha li khone ho sebetsa hantle kapa ho holofala. Acetylcholineke neurotransmitter e 'ngoe bokong e thusang ho ithuta le ho hopola. Ha ts'ebetso ea li-receptor tsa acetylcholine e fokotseha, maikutlo a neuronal a fokotseha. Sena se bolela hore li-neurone li fokola haholo hore li ka amohela matšoao a kenang.

• Ho ruruha

Ho molemo ha ho ruruha e le karolo ea phekolo ea tlhaho ea 'mele. Empa ha maemo a qala ho baka ho ruruha ho sa foleng, mathata a tebileng a ka hlaha. Boko bo phetseng hantle bo sebelisa microglia ho itšireletsa khahlanong le likokoana-hloko. Ha motho a e-na le Alzheimer's, boko bo bona li-node tsa tau le liprotheine tsa beta-amyloid e le likokoana-hloko, e leng se bakang maikutlo a sa foleng a "neuro-inflammatory" a ikarabellang bakeng sa tsoelo-pele ea Alzheimer's.

• mafu a sa foleng

Ho ruruha ke ntho e tlatsetsang lefung la Alzheimer. Lefu leha e le lefe le bakang ho ruruha le ka kenya letsoho ho nts'etsopele ea 'dementia' kapa Alzheimer's ho batho ba hōlileng. Mafu ana a amanang le Alzheimer's a kenyelletsa herpesvirus ea batho 1 le 2 (HHV-1/2), cytomegalovirus (CMV), picornavirus, kokoana-hloko ea lefu la Borna, chlamydia pneumoniae, Helicobacter pylori, Borrelia spirochetes (lefu la Lyme), porphyromonas gingivalis, le Treponema. 

Matšoao a Alzheimer's

Lefu la Alzheimer lea fokola, ho bolelang hore le mpefala ha nako e ntse e ea. E etsahala ha likamano pakeng tsa lisele tsa boko tse bitsoang li-neurone le lisele tse ling tsa boko li senyeha. 

Matšoao a tloaelehileng haholo ke ho lahleheloa ke mohopolo le ho ferekana kelellong. Le hoja ho e-na le ho lahleheloa ke mohopolo hanyenyane qalong, matšoao a matla a kang ho se khone ho bua kapa ho itšoara ho ba bang a hlaha likarolong tsa morao tsa lefu lena. Matšoao a mang a lefu la Alzheimer ke:

• bothata ba ho tsepamisa maikutlo, 
• Bothata ba ho etsa mosebetsi o tloaelehileng 
• Pherekano
• Ho tepella maikutlo kapa matšoenyeho ho phatloha, 
• pherekano 
• Se lahlehe habonolo
• khokahanyo e mpe, 
• Mathata a mang a ’mele
• Mathata a puisano

Ha lefu lena le ntse le tsoela pele, batho ba na le mathata a ho rarolla mathata, ho boloka tlaleho ea lichelete le ho etsa liqeto tsa bohlokoa. Ha matšoao a ntse a mpefala, bakuli ba Alzheimer ba ka 'na ba se ke ba elelloa malapa a bona, ba thatafalloa ke ho metsa, ba tšoha 'me ba hloka tlhokomelo ea kamehla.

Lintho tse Kotsing tsa Lefu la Alzheimer

Ka kakaretso lefapha la tsa bongaka le lumela hore lefu la Alzheimer le bakoa ke motsoako oa liphatsa tsa lefutso le mabaka a mang a kotsi ho e-na le sesosa se le seng. Lintho tse kotsi bakeng sa lefu la Alzheimer li kenyelletsa:

• histori ea lelapa

Batho ba nang le mong ka bona oa boemo ba pele ba nang le lefu la Alzheimer ba na le kotsi e eketsehileng ea lefu lena.

• lilemo

Kotsi ea ho ba le Alzheimer's e imena habeli lilemo tse ling le tse ling tse hlano kamora ho ba lilemo li 65.

• Ho tsuba

Ho tsuba ho tlatsetsa ho nts'etsopele ea 'dementia', ho kenyelletsa le Alzheimer's, kaha e eketsa ho ruruha le ho fokotsa phallo ea mali mothapong.

• Mafu a pelo

ts'ebetsong ea boko, bophelo bo botle ba pelo e bapala karolo e kgolo. Boemo leha e le bofe bo senyang tsamaiso ea ho potoloha ha mali bo eketsa kotsi ea lefu la Alzheimer, ho akarelletsa lefu la pelo, stroke, khatello e phahameng ea mali, tsoekere e phahameng maling, k’holeseterole le mathata a valve.

• kotsi e sithabetsang ya boko

Tšenyo ea boko ka lebaka la kotsi e baka ho se sebetse hantle ha boko le ho shoa ha lisele tsa boko, 'me ke kotsi e kholo ea lefu la Alzheimer's.

• Mokhoa oa bophelo o sa pheleng hantle le lijo tse sa jeng hantle

Bafuputsi ba bitsa lefu la Alzheimer's lefu la sejoale-joale hobane ho ata ha lefu lena ho eketsehile ka ho ata ha lijo tse sa pheleng hantle litsong tsa sejoale-joale.

• mathata a boroko

Ba nang le mathata a nako e telele a ho robala ba ekelitse ho bokellana ha li-plaque tsa beta-amyloid bokong ba bona.

• ho hanyetsa insulin

Karolo ea mashome a robeli lekholong ea bakuli ba Alzheimer ho hanyetsa insulin kapa mofuta oa 2 lefu la tsoekere e na le. Ho hanyetsa insulin nako e telele ho ka lebisa ho lefu la Alzheimer's.

• khatello ea kelello

Khatello ea nako e telele kapa e tebileng ke sesosa sa kotsi bakeng sa lefu la Alzheimer's. 

• aluminium

Aluminium ke ntho e chefo liseleng tsa methapo 'me e ka baka lefu la Alzheimer's.

• testosterone e tlase

Ha re ntse re tsofala, maemo a testosterone a fokotseha ho banna le basali. Sena se eketsa kotsi ea lefu la Alzheimer.

Kalafo ea Lefu la Alzheimer

• Lefu la Alzheimer ke lefu le sa phekoleheng. Liphekolo tsa morao-rao tsa meriana li etselitsoe ho shebana le matšoao a lefu lena ho fapana le sesosa se ka sehloohong.
• Hobane lefu lena mohlomong ha le na sesosa le le leng, pheko ea 'nete ea Alzheimer's e kanna ea se ke ea fumanoa.
• Bafuputsi ba ntse ba tsoela pele ho hlahloba liphekolo tsa beta-amyloid le tau protheine e le pheko e ka khonehang bakeng sa Alzheimer's.
• Lithethefatsi tsa Alzheimer li etselitsoe ho ntlafatsa bophelo ba bakuli.
• Kaha liphekolo tsa morao-rao tsa meriana li lebisa tlhokomelo matšoaong a lefu la Alzheimer, bakuli ba bangata ba Alzheimer le bona ba noa meriana ho laola boitšoaro ba bona.
• Ha lisele tsa boko li senyeha, ho ka ’na ha hlokahala meriana le liphekolo tse ling ho laola ho teneha, ho tšoenyeha, ho tepella maikutlo, ho hlobaela, ho bona lintho tse bonahalang le mathata a mang a boitšoaro a bakoang ke lefu la Alzheimer.

Ke Eng e Molemo Bakeng sa Lefu la Alzheimer?

Ho na le liphekolo tsa tlhaho tse atlehang ho imolla matšoao a lefu la Alzheimer. Liphekolo tsena li khothalletsa bophelo bo botle, ho thibela lefu lena nako e telele le ho thibela ho qala ha 'dementia' le mathata a mang a boko.

• boitlhakiso ba mmele

Ho ikoetlisa ho na le phello e kholo bophelong ba boko. Bakuli ba Alzheimer ba tsamaeang khafetsa ba sebetsa hantle mesebetsing le ho tepella maikutlo Ketsahalo ea mathata a mang a bophelo bo botle ba kelello, joalo ka

• mosebetsi wa kelello

Ho koetlisa boko ho bohlokoa joaloka ho sebetsa mesifa. Mosebetsi oa kelello o itekanetseng o fokotsa liphello tsa lefu lena nakong ea bohareng ba bophelo. Ba nang le kelello e mafolofolo ha ba na monyetla oa ho tšoaroa ke lefu la Alzheimer.

Liketso tsa kelello tse kang ho bapala lipapali, ho rarolla lipuzzle, le ho bala li thusa ho lula u phetse hantle ha u ntse u tsofala.

• Vithamine E

Lithuto, Vithamine ELiphetho li bonts'a hore e liehisa neurodegeneration ho bakuli ba nang le lefu la Alzheimer's le mahareng ho isa ho le matla. Lefu la Alzheimer le baka tšenyo ea oxidative. Ka hona, li-antioxidants tse kang vithamine E li na le monyetla oa ho ba phekolo ea lefu lena.

• Vithamine D

Vithamine DE hlahisoa ha letlalo le pepesehetse mahlaseli a letsatsi. E sebetsa le calcium ho haha ​​masapo a matla. E thusa ho laola sesole sa 'mele 'me e bohlokoa bakeng sa potoloho ea bophelo ea lisele tsa motho tse kang lisele tsa boko.

Bakuli ba bangata ba nang le lefu la Alzheimer le mafu a mang a 'dementia' ba haelloa ke vithamine D. Ho pepesetsoa khanya ea tlhaho ho khothalletsa boroko bo botle, haholo-holo ho bakuli ba nang le lefu le matla la Alzheimer's.

• Melatonin

Ho phaella ho robala hantle melatoninE na le melemo e mengata ho ba nang le lefu la Alzheimer. Phuputso ea morao tjena e ile ea hlahloba katleho ea melatonin e le phekolo ea ho thibela nitric oxide ho bakuli ba Alzheimer. Bakuli ba Alzheimer ba na le ts'ebetso e tlase ea melatonin receptors MT1 le MT2.

• potasiamo le manganese

khaello ea manganese Ke kotsi ea lefu la Alzheimer. E lekaneng potasiamo Ntle le eona, 'mele o ke ke oa sebetsana le beta-amyloids hantle mme ho eketseha ha khatello ea oxidative le ho ruruha ho bonoa.

Ho eketseha ha potasiamo le magnesium ho ntlafatsa ts'ebetso ea kelello le ho thibela ho qala ha lefu la Alzheimer's.

• dimela tsa tlhaho

Limela li na le lintho tse ngata tsa ho tsosolosa le ho folisa. Ho na le litlama tse itseng tse ka susumetsang tšebetso ea boko e hlokahalang ho thusa ho thibela lefu la Alzheimer.

remoremo remo remo ve mofereferee 'nile ea hlokomeloa hore e na le liphello tse molemo ho bakuli ba Alzheimer's. Ka lebaka la thepa ea eona e khahlanong le ho ruruha le ea antioxidant, curcumin e ntlafatsa ts'ebetso ea kelello ka ho fokotsa ho thehoa ha li-plaque tsa beta-amyloid.

• ketosis

Ketosis ke tšebeliso ea mafura a bolokiloeng bakeng sa matla. Ha 'mele o fanoa ka li-ketone tse loketseng, tse kang li-triglycerides tse mahareng tse fumanoang oli ea kokonate, bakuli ba Alzheimer ba ka ntlafatsa mohopolo oa bona.

Ho khothaletsa ketosis, ho khothaletsa 'mele ho sebelisa mafura ho fapana le tsoekere ho itima dijo nako le nako le lik'habohaedreite tse tlase lijo tsa ketogenic e sebetsang. Ha o le ketosis, 'mele o hlahisa khatello e fokolang ea oxidative mme o fana ka matla a mitochondrial bokong. Ts'ebetso ena e fokotsa maemo a glutamate mme e khothalletsa ts'ebetso ea boko bo phetseng hantle.

• oli ea mohloaare

Ho sebelisa oli ea mohloaare e le lijo Lijo tsa Mediterraneane bontšitse liphello tse molemo ho bakuli ba Alzheimer. Litekong tsa liphoofolo, oli ea mohloaare e ile ea ntlafatsa mohopolo le ho khothalletsa ho hōla ha lisele tse ncha. oli ea mohloaareKaha e sebetsa ho fokotsa sebopeho sa plaque ea beta-amyloid, e ka lieha le ho thibela ho qala ha lefu la Alzheimer.

Litšupiso: 1, 2