Zviratidzo zveAlzheimer - Chii Chakanakira Chirwere cheAlzheimer?

Chirwere cheAlzheimer ndiyo inonyanya kuzivikanwa mhando yedementia. Chirwere ichi chinokonzera matambudziko nekukwanisa kweuropi kurangarira, kufunga, uye kuita nemazvo. Zviratidzo zveAlzheimer's zvinosanganisira kuvhiringika, kuomerwa nekuita mabasa emazuva ese, matambudziko ekutaurirana, kunetseka kuisa pfungwa.

Chirwere ichi chinokura kwenguva yakareba. Zviratidzo zveAlzheimer zvinowedzera kukura nekukura uye pakupedzisira munhu haakwanise kuita basa rake remazuva ese. Kunyange hazvo chirwere ichi chichiwanzoonekwa muvanhu vane makore anodarika makumi matanhatu nemashanu, kunewo vanotanga chirwere ichi vachiri vadiki. Vamwe vanogona kurarama nechirwere ichi kwenguva yakareba semakore makumi maviri, nepo avhareji yemakore anotarisirwa ari masere.

Chirwere ichi chinofungidzirwa kuti chirwere chemazuva ano uye chinofungidzirwa kubata vanhu 2050 miriyoni mugore ra16.

Chii Chinokonzera Alzheimer's?

Zvidzidzo pamusoro pezvinokonzeresa Alzheimer's, degenerative brain disorder, enderera uye zvinhu zvitsva zvinodzidzwa mazuva ese. Parizvino, chete zvikonzero zvinokonzera kukanganisa neuronal iyo inoratidza chirwere chinogona kuonekwa. Iko hakuna ruzivo rwakakwana rwekuti chii chaizvo chinoikonzera. Zvikonzero zvinozivikanwa zvechirwere cheAlzheimer zvinogona kunyorwa sezvizvi;

• beta-amyloid plaque

Kuwanda kwakanyanya kwebeta-amyloid mapuroteni kunoonekwa muuropi hwevazhinji varwere veAlzheimer. Aya mapuroteni anoshanduka kuita plaque munzira neuronal, kukanganisa kushanda kwehuropi.

• Tau protein nodes 

Sezvinongoita mapuroteni ebeta-amyloid muhuropi hwevarwere veAlzheimer anoungana kuita plaque, mapuroteni etau anoumba neurofibrillary tangles (NFTs) inokanganisa kushanda kwehuropi. Kana tau ikakura kuita sebvudzi semasumbu anonzi NFTs, inovharira sisitimu yekufambisa uye inodzivirira kukura kwesero. Zvadaro zviratidzo zve synaptic zvinokundikana. Tau protein tangles chiratidzo chechipiri chechirwere cheAlzheimer uye saka inzvimbo yakakosha yekutarisisa kune vaongorori vari kudzidza chirwere ichi.

• Glutamate uye acetylcholine 

Uropi hunoshandisa makemikari anonzi neurotransmitters kutumira zviratidzo pakati peeuroni. Kana glutamate ikanyanya kushanda, inoisa kushushikana pane neuroni dzinoita ndangariro uye cognition. Toxic stress mazinga anoreva kuti ma neuron haagone kushanda zvakanaka kana kukanganisa. Acetylcholinendeimwe neurotransmitter muuropi iyo inobatsira kudzidza nekuyeuka. Apo basa reacetylcholine receptors rinoderera, neuronal sensitivity inoderera. Izvi zvinoreva kuti ma neuron haana kusimba kuti agamuchire zviratidzo zvinouya.

• Kuzvimba

Zvinobatsira kana kuzvimba kuri chikamu chekupora kwemuviri. Asi kana mamiriro ezvinhu atanga kugadzira kuzvimba kusingaperi, matambudziko akakomba anogona kumuka. Uropi hune hutano hunoshandisa microglia kudzivirira kubva kune hutachiona. Kana mumwe munhu aine Alzheimer's, uropi hunoona tau node uye beta-amyloid mapuroteni sehutachiona, zvichikonzera kusagadzikana kweurouro-kuzvimba izvo zvinokonzeresa kufambira mberi kweAlzheimer.

• zvirwere zvisingaperi

Kuzvimba ndicho chinhu chinokonzera chirwere cheAlzheimer. Chero chirwere chinokonzera kuzvimba chinogona kubatsira mukukura kwedementia kana Alzheimer's kune vakwegura. Izvi zvirwere zvinokonzerwa neAlzheimer's zvinosanganisira human herpesviruses 1 uye 2 (HHV-1/2), cytomegalovirus (CMV), picornavirus, Borna's disease virus, chlamydia pneumoniae, Helicobacter pylori, Borrelia spirochetes (chirwere cheLyme), porphyromonas gingivalis, uye Treponema. 

Zviratidzo zveAlzheimer

Chirwere cheAlzheimer chinopera simba, zvichireva kuti chinowedzera nekufamba kwenguva. Zvinoitika kana kubatana kuripo pakati pemaseru europi anonzi neurons nemamwe masero europi kwakakuvadzwa. 

Chiratidzo chinonyanyozivikanwa kutadza kuyeuka uye kuvhiringidzika mupfungwa. Nepo kune kuderera kwendangariro kurasikirwa munhanho yekutanga, zviratidzo zvakakomba sekutadza kutaura kana kuita kune vamwe zvinoitika mumatanho ekupedzisira echirwere. Zvimwe zviratidzo zvechirwere cheAlzheimer ndezvi:

• kunetseka kuisa pfungwa, 
• Kunetseka kuita basa rakajairika 
• Kuvhiringidzika
• Kushungurudzika kana kufunganya kuputika, 
• disorientation 
• Usarasike nyore
• kusarongeka zvakanaka, 
• Zvimwe zvinetso zvomuviri
• Matambudziko ekukurukurirana

Sezvo chirwere ichi chichienderera mberi, vanhu vane matambudziko neunyanzvi hwekugadzirisa matambudziko, kuchengetedza mari, uye kuita sarudzo dzakakosha. Sezvo zviratidzo zvichiwedzera, varwere veAlzheimer vangasaziva mhuri yavo, vane dambudziko rekumedza, vanova neshungu uye vanoda kugara vachitarisirwa.

Chirwere cheAlzheimer Risk Factors

Vezvekurapa vanowanzo tenda kuti chirwere cheAlzheimer chinokonzerwa nekusanganiswa kwemajini uye zvimwe zvinhu zvine njodzi kwete chikonzero chimwe chete. Zvinokonzera njodzi yechirwere cheAlzheimer zvinosanganisira:

• nhoroondo yemhuri

Vanhu vane dhigirii rekutanga hama vane Alzheimer's vane njodzi yakawedzera yechirwere ichi.

• zera

Ngozi yekuva neAlzheimer yakapetwa kaviri makore mashanu ega ega mushure mekusvitsa makumi matanhatu neshanu.

• Kusvuta

Kusvuta kunobatsira mukukura kwedementia, kusanganisira Alzheimer's, sezvo inowedzera kuzvimba uye inoderedza kuyerera kweropa mutsinga.

• Zvirwere zvemwoyo

mukushanda kwehuropi, utano hwemwoyo inoita basa guru. Chero mamiriro ezvinhu anokuvadza kutenderera kweropa anowedzera njodzi yeAlzheimer's, kusanganisira chirwere chemoyo, sitiroko, BP, high blood sugar, cholesterol, uye mavharuvhu matambudziko.

• kukuvara kwehuropi

Kukuvadzwa kwehuropi nekuda kwekukuvara kunokonzera kukanganisa kushanda kwehuropi uye kufa kwemasero europi, uye iri njodzi huru yechirwere cheAlzheimer.

• Mararamiro asina kunaka uye kudya kwakashata

Vatsvakurudzi vanodana Alzheimer's chirwere chemazuva ano nokuti kuwanda kwechirwere kwakawedzera nekuwanda kwezvokudya zvisina kunaka mumagariro emazuva ano.

• matambudziko ekurara

Avo vane matambudziko ekurara kwenguva refu vakawedzera kuunganidzwa kwebeta-amyloid plaques muhuropi hwavo.

• insulin kuramba

Makumi masere muzana evarwere veAlzheimer insulin kuramba kana Type 2 chirwere cheshuga ane. Kuramba insulin kwenguva refu kunogona kutungamirira kuchirwere cheAlzheimer.

• Kushungurudzika

Kushungurudzika kwenguva refu kana kwakadzika chinhu chinokonzera njodzi yeAlzheimer's. 

• aruminiyamu

Aluminium chinhu chine chepfu kumasero etsinga uye chinogona kukonzera chirwere cheAlzheimer.

• testosterone yakaderera

Sezvatinokura, mazinga e testosterone anoderera muvarume nevakadzi. Izvi zvinowedzera njodzi yechirwere cheAlzheimer.

Kurapa Kwechirwere cheAlzheimer

• Alzheimer's chirwere chisingarapike. Mishonga yemazuva ano yemishonga yakagadzirirwa kutarisa zviratidzo zvechirwere panzvimbo pechikonzero chinokonzera.
• Nekuti chirwere ichi pamwe hachina chikonzero chimwe chete, mushonga chaiwo weAlzheimer unogona kusawanikwa.
• Vatsvakurudzi vanoramba vachiongorora zvose beta-amyloid uye tau protein mishonga sezvinobvira kurapa kweAlzheimer's.
• Mishonga yeAlzheimer inonyanya kugadzirirwa kuvandudza mararamiro evarwere.
• Nekuda kwekuti marapiro emazuva ano emishonga anonangana nezviratidzo zvechirwere cheAlzheimer, varwere vazhinji veAlzheimer vanotorawo mishonga kuti vadzore maitiro avo.
• Kana masero europi aora, mushonga uye kumwe kurapa kungadiwa kudzora kushatirwa, kuzvidya mwoyo, kuora mwoyo, kusarara zvakanaka, kuona zvinhu zvisipo, uye zvimwe zvirwere zveAlzheimer's.

Chii Chakanakira Chirwere cheAlzheimer?

Kune marapirwo echisikigo anoshanda mukubvisa zviratidzo zveAlzheimer. Mishonga iyi inokurudzira hupenyu hune hutano, kudzivirira chirwere kwenguva yakareba uye kudzivirira kutanga kwedementia uye mamwe matambudziko europi.

• basa remuviri

Kuita maekisesaizi kune simba guru pahutano hwehuropi. Varwere veAlzheimer vanofamba nguva dzose vanoita zvirinani mumabasa uye kusuruvara Chiitiko chemamwe matambudziko ehutano hwepfungwa, akadai

• kushanda kwepfungwa

Kudzidzisa huropi kwakakosha sekushanda mhasuru. Kushanda kwepfungwa kwakadzikama kunoderedza migumisiro yechirwere mukati memidlife. Avo vane pfungwa dzakasimba havanyanyi kuva nechirwere cheAlzheimer.

Zviitiko zvepfungwa zvakadai sekutamba mitambo, kugadzirisa mapuzzle, uye kuverenga zvinobatsira kugara wakagwinya sezvaunokura.

• Vitamin E

Zvidzidzo, Vitamin EMhedzisiro yacho inoratidza kuti inononoka neurodegeneration muvarwere vane mwero kusvika kune yakanyanya chirwere cheAlzheimer. Alzheimer's inokonzera oxidative kukuvara. Naizvozvo, ma antioxidants akadai sevhitamini E ane mukana wekuva mushonga wechirwere.

• Vitamin D

Vitamin DInogadzirwa apo ganda rinosangana nechiedza chezuva. Inoshanda ne calcium kuvaka mapfupa akasimba. Inobatsira kudzora immune system uye yakakosha kutenderera kwehupenyu hwemasero emunhu senge masero europi.

Varwere vazhinji vane Alzheimer's nezvimwe zvirwere zvedementia havana vhitamini D. Kuratidzwa kuchiedza chechisikigo kunokurudzira kurara kune hutano, kunyanya muvarwere vane chirwere cheAlzheimer chakakomba.

• Melatonin

Mukuwedzera pakurara zviri nani melatoninIine zvakawanda zvinobatsira kune avo vane chirwere cheAlzheimer. Ongororo ichangoburwa yakaongorora kushanda kwe melatonin semushonga wekuvharisa nitric oxide muvarwere veAlzheimer. Varwere veAlzheimer vane basa rakaderera re melatonin receptors MT1 uye MT2.

• manganese uye potassium

kushaya manganese Icho chinokonzera njodzi yechirwere cheAlzheimer. Zvakakwana potasium Pasina iyo, muviri haugone kugadzirisa beta-amyloids nemazvo uye kuwedzera muoxidative kusagadzikana uye kuzvimba kunoonekwa.

Kuwedzera potassium uye magnesium kudya kunovandudza kugona kwekuziva uye kunodzivirira kutanga kwechirwere cheAlzheimer.

• zvinomera zvakasikwa

Zvirimwa zvine zvakawanda zvinodzorera uye zvinoporesa zvinhu. Kune mamwe maruva anogona kukurudzira maitiro ehuropi anodiwa kubatsira kudzivirira chirwere cheAlzheimer.

nesafironi ve turmericzvakaonekwa kuti zvine migumisiro inobatsira kune varwere veAlzheimer. Nekuda kweiyo anti-inflammatory uye antioxidant properties, curcumin inovandudza cognitive basa nekuderedza kuumbwa kwebeta-amyloid plaques.

• ketosis

Ketosis ndiko kushandiswa kwemafuta akachengetwa kwesimba. Kana muviri ukapihwa maketoni akakodzera, akadai sepakati-ketani triglycerides inowanikwa mukokonati mafuta, varwere veAlzheimer vanogona kuvandudza ndangariro yavo.

Kukurudzira ketosis, kukurudzira muviri kushandisa mafuta panzvimbo yeglucose kutsanya kwepakati uye yakaderera mumacarbohydrates ketogenic kudya zvinoshanda. Kana uri mu ketosis, muviri unogadzira kushomeka kweoxidative kusagadzikana uye unopa hunoshanda mitochondrial simba kuuropi. Iyi nzira inoderedza mazinga e glutamate uye inosimudzira hutano hunoshanda hwehuropi.

• namafuta

Kushandisa mafuta omuorivhi sechikafu Kudya kweMediterraneanyakaratidza migumisiro inobatsira muvarwere veAlzheimer. Mukuedza kwemhuka, mafuta omuorivhi akavandudza chiyeuchidzo uye akakurudzira kukura kwemasero matsva. namafutaSezvo ichiita kuderedza kuumbwa kwebeta-amyloid plaque, inogona kunonoka uye kudzivirira kutanga kwechirwere cheAlzheimer.

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