Iyini i-Obesogen? Yini I-Obesogens Ebangela Ukukhuluphala?

Ama-obesogensngamakhemikhali okwenziwa okucatshangwa ukuthi adala ukukhuluphala. Itholakala ezitsheni zokudla, amabhodlela okuphakelayo, amathoyizi, amapulasitiki, izinto zokupheka, nezimonyo.

Uma la makhemikhali engena emzimbeni womuntu, adala ukugcotshwa ngokuphazamisa ukusebenza kwawo okuvamile. I-Obesogen Kunamakhemikhali angaphezu kwama-20 achazwa ngokuthi

Yini i-obesogen?

Ama-obesogensngamakhemikhali okwenziwa atholakala ezitsheni zokudla, izinto zokupheka, namapulasitiki. Kuyi-subset yamakhemikhali aphazamisa i-endocrine.

Lawa makhemikhali kucatshangwa ukuthi abangela ukukhuluphala. Uma umuntu echayeka kulawa makhemikhali ngesikhathi sokukhula, ukuthambekela kwabo ekuba nesisindo kuyakhula kukho konke ukuphila kwakhe ngokuphazamisa izinqubo zabo ezivamile ze-metabolic.

Ama-obesogens Akubangeli ukukhuluphala ngokuqondile, kodwa kwandisa ukuzwela ekuzuzeni isisindo.

Izifundo, ama-obesogensUcwaningo lubonisa ukuthi ikhuthaza ukukhuluphala ngokuphazamisa isifiso sokudla kanye nokulawula ukusutha. Ngamanye amazwi, ishintsha indlela umzimba olawula ngayo imizwa yendlala nokusutha.

Asebenza kanjani ama-obesogens?

ama-obesogensyiziphazamisi ze-endocrine eziphazamisa amahomoni. Abanye abaphazamisi be-endocrine benza kusebenze ama-estrogen receptors, angabangela imiphumela eyingozi kokubili amadoda nabesifazane. 

abanye ama-obesogens kubangela ukukhubazeka kokuzalwa, ukuthomba ngaphambi kwesikhathi emantombazaneni, inzalo kubafana, umdlavuza webele nezinye izifo.

Iningi lale miphumela yenzeka esibelethweni. Ngokwesibonelo, lapho abesifazane abakhulelwe bechayeka kula makhemikhali, izingane zabo zisengozini enkulu yokukhuluphala kamuva ekuphileni.

Yini Ama-Obesogens?

I-Bisphenol-A (BPA)

I-Bisphenol-A (BPA)Kuyinhlanganisela yokwenziwa etholakala emikhiqizweni eminingi njengamabhodlela okuphakelayo, ukudla kwepulasitiki namathini eziphuzo. Isetshenziswe emikhiqizweni yokuhweba iminyaka eminingi.

Isakhiwo se-BPA sifana ne-estradiol, uhlobo olubaluleke kakhulu lwe-hormone ye-estrogen. Ngakho-ke i-BPA ibophezela kuma-estrogen receptors emzimbeni.

Indawo ezwela kakhulu ku-BPA isesibelethweni. Ucwaningo luye lwabonisa ukuthi ukuchayeka kwe-BPA kubangela ukuzuza kwesisindo. futhi ukumelana ne-insulinkubangela isifo senhliziyo, isifo sikashukela, ukuphazamiseka kwezinzwa, ukuphazamiseka kwegilo.

phthalates

Ama-Phthalates ngamakhemikhali enza amapulasitiki athambe futhi aguquguquke. Itholakala emikhiqizweni eyahlukene njengamabhokisi okudla, amathoyizi, imikhiqizo yobuhle, imithi, amakhethini eshawa, nopende. Lawa makhemikhali aphuma kalula kumapulasitiki. Kungcolisa ukudla, amanzi kanye nomoya esiwuphefumulayo.

Njenge-BPA, ama-phthalates ayiziphazamisi ze-endocrine ezithinta ibhalansi ye-hormonal emzimbeni wethu. Yandisa ukuzwela ekuzuzeni isisindo ngokuthinta ama-hormone receptors abizwa ngokuthi ama-PPAR abandakanyeka kumetabolism. Idala ukumelana ne-insulin.

Ikakhulukazi amadoda azwela kakhulu kulezi zinto. Ucwaningo lubonisa ukuthi ukuchayeka kwe-phthalate kuholela kumasende aphansi kanye namazinga aphansi e-testosterone.

I-Atrazine

I-Atrazine ingenye yemithi yokubulala ukhula esetshenziswa kakhulu. I-Atrazine iphinde ibe isiphazamisi se-endocrine. Ucwaningo lubonisa ukuthi kuhlobene nokuzala okukhubazekile kubantu.

Kuye kwanqunywa ukulimaza i-mitochondria, ukunciphisa izinga le-metabolic futhi kwandise ukukhuluphala kwesisu kumagundane.

ama-organotins

Ama-Organotin yikilasi lamakhemikhali okwenziwa asetshenziswa embonini. Enye yazo ibizwa ngokuthi i-tributyltin (TBT).

Isetshenziswa njengesibulala-sikhunta futhi isetshenziswa ezikebheni nasemikhunjini ukuvimbela ukukhula kwezinto eziphilayo zasolwandle. Isetshenziswa njengesilondolozi sezinkuni nakwezinye izinhlelo zamanzi zezimboni. Amachibi amaningi namanzi asogwini angcoliswe i-tributyltin.

I-Tributyltin iyingozi ezintweni zasolwandle. Ososayensi bacabanga ukuthi i-tributyltin nezinye izinhlanganisela ze-organotin zingasebenza njengeziphazamisi ze-endocrine ngokwandisa inani lamaseli amafutha.

I-Perfluorooctanoic acid (PFOA)

I-Perfluorooctanoic acid (PFOA) iyinhlanganisela yokwenziwa esetshenziselwa izinhloso ezahlukahlukene. Isetshenziswa ku-cookware engagxili njenge-Teflon.

izifo ze-thyroid futhi uhlotshaniswe nezifo ezihlukahlukene ezifana nesifo sezinso esingamahlalakhona.

Ocwaningweni lwamagundane, ukuchayeka ekuthuthukisweni kwe-PFOA kuholele ekwandeni kwesisindo somzimba impilo yonke nge-insulin ne-leptin yehomoni.

I-Polychlorinated biphenyls (PCBs)

Ama-PCB angamakhemikhali enziwe umuntu asetshenziswa emakhulwini ezinto ezisetshenziswa ezimbonini nezohwebo, njengezibala zemibala ephepheni, amapulasitiki opende, amapulasitiki nemikhiqizo yenjoloba, nezinto zikagesi. 

Iqoqana emaqabunga, izitshalo kanye nokudla, ingena emizimbeni yezinhlanzi nezinye izinto eziphilayo ezincane. Azibhidliki kalula ngemva kokungena endaweni.

ku-Current Pharmaceutical Biotechnology Ngokocwaningo olushicilelwe, ama-PCB ahlotshaniswa nokukhuluphala, ukumelana ne-insulin, uhlobo 2 sikashukela kanye nokuthuthukiswa kwe-metabolic syndrome.

Unganciphisa kanjani ukuthintana nama-obesogens?

Kunamakhemikhali amaningi aphazamisa uhlelo lwe-endocrine esihlangana nawo. Akunakwenzeka ukuwasusa ngokuphelele ezimpilweni zethu, ngoba zikhona yonke indawo. Kodwa kungenzeka ukunciphisa kakhulu ukuchayeka:

• Gwema ukudla neziphuzo ezigcinwe ezitsheni zepulasitiki.
• Sebenzisa insimbi engagqwali noma amabhodlela amanzi e-aluminium ekhwalithi esikhundleni sepulasitiki.
• Ungayiphakeli ingane yakho ngamabhodlela epulasitiki. Kunalokho sebenzisa ibhodlela lengilazi.
• Sebenzisa insimbi ecijile noma insimbi engagqwali esikhundleni sezinto zokupheka ezinganamathi.
• Sebenzisa izithako zemvelo, zezimonyo zemvelo.
• Ungasebenzisi amapulasitiki ku-microwave.
• Sebenzisa imikhiqizo engenamakha.
• Ungathengi okhaphethi abangavimbeli amabala noma abangashi noma ifenisha.
• Yidla ukudla okusha (izithelo nemifino) noma nini lapho kungenzeka.