Grape seed extract (GSE)It is a dietary supplement obtained by extracting the bitter seeds of grapes, drying and powdering them.
Grape seeds are rich in antioxidants such as phenolic acids, anthocyanins, flavonoids and oligomeric proanthocyanidin complexes (OPCs).
Actually, grape seed extract It is one of the best known sources of proanthocyanidins.
Due to its high antioxidant content, it protects against oxidative stress, tissue damage and inflammation and prevents disease.
What Are the Benefits of Grape Seed Extract?
Reduces blood pressure
Some studies grape seed extract investigated its effects on high blood pressure.
Meta-analysis of 810 studies in 16 people with high blood pressure or at risk of high blood pressure, grape seed extract has examined its effect on this situation.
They found that taking 100--2,000 mg per day significantly reduced systolic blood pressure (upper number), with an average of 6.08 mmHg and diastolic blood pressure (lower number) 2.8 mmHg.
Those under the age of 50 who were obese or had metabolic disorders showed the biggest improvements.
The most promising results were obtained from low doses of 800-8mg daily for 16–100 weeks, with a single dose of 800mg or more.
In another study in 29 adults with high blood pressure, 300 mg grape seed extract It was found to reduce systolic blood pressure by 5,6% and diastolic blood pressure by 4.7% after six weeks.
Improves blood flow
Some studies grape seed extract It suggests that it can improve blood flow.
In an eight-week study of 17 postmenopausal women, taking 400 mg was found to have a thinning effect on the blood and potentially reduce the risk of blood clots.
A study conducted in eight healthy young women, from grape seed extract The effects of a single 400 mg dose of proanthocyanidin taken were evaluated.
Grape Seed Extract Leg swelling and edema of the areas were reduced by 70% compared to those who did not take it.
In the same study, for 14 days from grape seed extract Eight healthy women who took 133 mg of proanthocyanidin daily experienced 8% less leg swelling after six hours of sitting.
Decreases oxidative damage
Increased blood levels of "bad" LDL cholesterol is a known risk factor for heart disease.
Oxidation of LDL cholesterol significantly increases this risk and plays a central role in atherosclerosis or the deposition of fatty plaques in the arteries.
Grape Seed Extract supplementation has been found to reduce LDL oxidation induced by high-fat diets in several animal studies.
When eight healthy people eat a high-fat meal, 300 mg grape seed extractinhibited the oxidation of fats in the blood, grape seed extract compared to a 150% increase seen in those who did not take it.
In another study, 61 healthy adults saw a 400% reduction in oxidized LDL after taking 13.9 mg.
Additionally, in one study in 87 people who had heart surgery, 400 mg given the day before surgery grape seed extract It has been found to significantly reduce oxidative stress.
Improves collagen and bone strength
It has been proven that increasing flavonoid consumption improves collagen synthesis and bone formation.
As a rich source of flavonoids, grape seed extract It helps to increase bone density and strength.
Animal studies have shown that a low-calcium, standard or high-calcium diet grape seed extract found that supplementing it can increase bone density, mineral content, and bone strength.
Rheumatoid arthritis is an autoimmune condition that results in severe inflammation and destruction of bones and joints.
Animal studies, grape seed extract It has shown that it suppresses bone resorption in inflammatory autoimmune arthritis.
Grape Seed Extract It also significantly reduced pain, bone marrow and joint damage, improved collagen, and reduced cartilage loss in osteoarthritic mice.
Despite the promising results of animal research, human studies are lacking.
Slows down the aging process of the brain
Flavonoids are thought to delay or reduce the onset of neurodegenerative diseases such as Alzheimer's disease with a combination of antioxidant and anti-inflammatory properties.
Grape Seed Extract One of its components is gallic acid, which appears to inhibit the formation of beta-amyloid peptides and fibrils in animal and laboratory settings.
Clusters of beta-amyloid proteins in the brain are characteristic of Alzheimer's disease.
Animal studies, grape seed extract It found that it can improve brain antioxidant and cognitive state, prevent memory loss, and reduce brain lesions and amyloid clusters.
In a 111-week study in 12 healthy older adults, 150 mg grape seed extract It has been found to improve attention, language, and both immediate and delayed memory.
Improves kidney function
Kidneys are particularly susceptible to irreversible oxidative damage.
Animal studies, grape seed extract It has shown that it can reduce kidney damage and improve function by reducing oxidative stress and inflammatory damage.
In one study, 23 people diagnosed with chronic kidney failure took 6 grams per day for 2 months. grape seed extract given and evaluated against the second non-intervention group. Urine protein decreased 3% and kidney filtration increased 9%.
This means their kidneys can filter urine better than the control group.
Inhibits infectious growth
Grape Seed Extract It shows promising antibacterial and antifungal properties.
Studies, grape seed extractCampylobacter, E. coli and Shiga toxins, which have shown to inhibit the growth of common foodborne bacterial infections - all of which are responsible for severe food poisoning and abdominal pain.
In the laboratory, grape seed extract antibiotic resistant Staphylococcus aureus It has been found to inhibit 43 species of bacteria.
Candida It is a yeast-like fungus that results in overgrowth or thrush. Grape Seed ExtractIt is widely used in traditional medicine as a remedy for candida.
Mice infected with vaginal candidiasis were given intravaginally every two days for eight days. grape seed extract solution was given. The infection was effectively inhibited after five days and was gone after the eighth day.
Unfortunately, grape seed extract Human studies on the effect on infectious growth are still lacking.
Reduces cancer risk
The causes of cancer are complex, but DNA damage is a central feature.
High intake of antioxidants such as flavonoids and proanthocyanidins is associated with a reduced risk of various cancers.
Grape Seed Extract demonstrated potent antioxidant activity, in vitro potential to inhibit human breast, lung, stomach, oral squamous cell, liver, prostate and pancreatic cell lines.
In animal studies grape seed extract Different types of chemotherapy have been shown to increase their effectiveness.
Grape Seed ExtractAppears to protect against oxidative stress and liver toxicity while targeting chemotherapy action on cancerous cells.
Protects the liver
The liver plays an important role in detoxifying harmful substances injected into our bodies through medications, viral infections, pollutants, alcohol and more.
Grape Seed Extract It has a protective effect on the liver.
In test tube studies grape seed extractreduced inflammation, recycled antioxidants and protected against free radical damage during toxin exposure.
The liver enzyme alanine aminotransferase (ALT) is an important marker of liver toxicity; This means that when the liver is damaged, levels rise.
In one study, 15 people with non-alcoholic fatty liver disease and subsequent high ALT levels were grape seed extract was given. Liver enzymes were monitored monthly and the results were compared with taking 2 grams of vitamin C per day.
Three months later grape seed extract group ALT decreased by 46%, while there was little change in the vitamin C group.
Provides healing of wounds and reduces scars
Some animal studies grape seed extract found that it helps wound healing. Human studies also support this.
35% of 2 healthy adults who had a minor operation grape seed extract conditioner or placebo was given. Those who used the cream experienced complete wound healing after eight days, while the placebo group took 14 days to heal.
This result is most likely in grape seed extract It is caused by the release of growth factors in the skin due to high proanthocyanidins.
In an 110-week study of 8 healthy young men, a 2% grape seed extract cream improved the skin's appearance, elasticity and sebum content; this helped reduce acne breakouts and helped the skin look better as it ages.
Protects male reproductive health
In animal experiments, grape seed extractIt has been shown to increase testosterone levels in male subjects as well as prevent testicular damage caused by chemicals and drugs.
This is probably due to its ability to block aromatase enzymes that convert androgens into estrogens.
Prevents hair loss
While more research is needed to confirm these results, preliminary studies grape seedsof antioxidants hair lossIt can be beneficial in reducing hair growth and indeed promoting new hair growth.
The compounds in this supplement stimulate hair follicles that promote new growth and prevent continuous hair loss.
Improves breathing
Asthma and seasonal allergies can affect the ability to breathe well.
Both of these conditions are caused by inflammation and an autoimmune response.
Grape Seed ExtractThe compounds in it are known to reduce airway inflammation, as well as reduce mucus production.
This can ease asthma symptoms.
By blocking the release of inflammatory markers, including histamine, it can also reduce allergic reactions similar to those seen in seasonal allergies.
Other possible benefits
Researchers grape seed extractAs we learn more about the benefits of the, there are promising new results for future applications.
For example, early research, grape seed extractIt has shown that the compounds found in can help treat or prevent tooth decay, alleviate diabetic retinopathy, treat chronic venous insufficiency, improve edema, and treat hemochromatosis.
More research is needed on these conditions.
However, cell and animal trials in these applications are promising.
What Are the Harms of Grape Seed Extract?
Grape Seed Extract it is generally considered safe with few side effects.
Dosages of about 8-16 mg per day for 300--800 weeks were safe and well tolerated in humans.
Pregnant or breastfeeding women should avoid this as there is insufficient data on its effects in these populations.
Grape Seed Extract It can lower blood pressure and increase blood flow, so caution is recommended for those taking blood thinners or blood pressure medications.
It can also reduce iron absorption as well as improve liver absorption and drug metabolism. Grape Seed Extract Consult your doctor before starting supplements.
As a result;
Grape seed extract (GSE)is a dietary supplement made from grape seeds.
It is a powerful source of antioxidants, especially proanthocyanidins.
In grape seed extract Antioxidants help alleviate oxidative stress, inflammation and tissue damage that can occur as well as chronic diseases in our body.
